Glutamine and Intestinal Protein Metabolism
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT00213551|
Recruitment Status : Completed
First Posted : September 21, 2005
Last Update Posted : June 18, 2013
Gut barrier plays a major role in defence of the organism. During catabolic states, like major surgery or inflammation, gut barrier could be altered. It has been reported that preoperative nutritional support may have beneficial effects on clinical outcome in patients with surgery on gastrointestinal tract. Glutamine, which is a conditionally essential amino, have been reported to modulate inflammatory, antioxidant responses and protein metabolism in intestine. In addition, glutamine supply improves clinical outcome in critically ill patients. Antioxidant micronutrients may also have some beneficial effects in intestine by improving antioxidant response and might also regulate protein expression. Nevertheless, effects of glutamine combined to antioxidant micronutrients have not been evaluated.
Thus, the aim of this study will be to assess the influence of glutamine and glutamine-antioxidant micronutrients-containing solutions on intestinal response in humans.
|Condition or disease||Intervention/treatment||Phase|
|Healthy Volunteers||Drug: Glutamine Drug: Glucose Drug: glutamine-antioxidants containing solution||Phase 1|
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||30 participants|
|Intervention Model:||Crossover Assignment|
|Masking:||None (Open Label)|
|Official Title:||Comparative Effects of Glutamine and Glucose on Intestinal Protein Metabolism in Healthy Humans|
|Study Start Date :||April 2004|
|Actual Study Completion Date :||June 2008|
- Impact on protein synthesis rate and proteolytic activities in intestine. [ Time Frame: at the end of infusion (hour 5) ]
- Comparison of protein expression pattern and glutathione synthesis. [ Time Frame: at the end of infusion (hour 5) ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00213551
|University Hospital of Rouen|
|Rouen, France, 76031|
|Principal Investigator:||Pierre Déchelotte, MD, PhD||University Hospital, Rouen|