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Small Bowel Motor Impairment in Scleroderma: Results of a Prospective 5-year Manometric Follow-up

This study has been completed.
Information provided by (Responsible Party):
University Hospital, Rouen Identifier:
First received: September 13, 2005
Last updated: April 15, 2013
Last verified: April 2013

Small bowel involvement is still recognized to be associated with great morbidity and mortality in SSc patients, leading particularly to malabsorption and intestinal pseudo-obstruction. Intestinal disorders directly related to SSc have, in fact, been reported to be one of the most common causes of death.

In a previous prospective study, we have demonstrated the high prevalence of small intestinal involvement in SSc patients, using upper intestinal manometry; in turn, 88% of our SSc patients had upper intestinal motor disturbances. However, to date, no authors have yet analyzed the course of upper intestinal motor dysfunction in SSc.

The aims of this study were therefore to assess the 5-year course of small bowel motor disorders, using manometry in patients with systemic sclerosis (SSc), and to investigate for an association between upper intestinal motor dysfunction outcome and other clinical manifestations of SSc.

Systemic Sclerosis

Study Type: Observational
Study Design: Time Perspective: Prospective
Official Title: Small Bowel Motor Impairment in Scleroderma: Results of a Prospective 5-year Manometric Follow-up

Resource links provided by NLM:

Further study details as provided by University Hospital, Rouen:

Study Start Date: August 2001
Study Completion Date: July 2003

Ages Eligible for Study:   18 Years to 80 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • patients with systemic sclerosis, who had an upper intestinal tract manometry 5 years before, with:

    • age over 18 years
    • written informed consent

Exclusion Criteria:

  • pregant women
  • patients with psychiatric conditions
  • unwritten informed consent
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Please refer to this study by its identifier: NCT00213460

CHU Rouen
Rouen, Rouen Cedex, France, 76031
Sponsors and Collaborators
University Hospital, Rouen
Principal Investigator: Isabelle MARIE, MD, PhD CHU Rouen
  More Information

Responsible Party: University Hospital, Rouen Identifier: NCT00213460     History of Changes
Other Study ID Numbers: 2000/103/HP
Study First Received: September 13, 2005
Last Updated: April 15, 2013

Additional relevant MeSH terms:
Scleroderma, Systemic
Scleroderma, Diffuse
Connective Tissue Diseases
Skin Diseases processed this record on May 23, 2017