Intravenous and Topical Analgesics for Procedural Pain in Neonates
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This study will test which type of pain medication is best for the management of pain in newborn preterm and full-term infants having a deep intravenous cannula inserted. It will compare the effectiveness of intravenous morphine alone, a local anaesthetic cream (amethocaine) alone, and both medications together. It will also determine the safety of both medications.
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Layout table for eligibility information
Ages Eligible for Study:
up to 30 Days (Child)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
preterm and full-term infants in the NICU requiring a percutaneous central venous catheter
ventilatory support in the form of conventional ventilation, Continuous Positive Air Pressure (CPAP) or High Frequency Oscillation(HFO)
receiving muscle relaxants
skin disorders causing disruption of stratum corneum