Study to Evaluate the Use of Ultrasound in the Diagnosis of Hemophilic Joint Disease
|Inherited Bleeding Disorders||Procedure: Power Doppler Sonography Procedure: MRI|
|Study Design:||Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Diagnostic
|Official Title:||Evaluation of the Role of Power Doppler Sonography in the Diagnosis of Hemophilic Joint Disease|
- Comparison of magnetic resonance imaging (MRI) and power Doppler sonograms on patients with target joint [ Time Frame: Up to 1 month ]
- Evaluation of PDS on patients with target joints pre and post synovectomy to assess response to therapeutic intervention [ Time Frame: 1. day of synovectomy; 2. 6 months post synovectomy. ]
- Evaluation of PDS on patients with at least 2 joint bleeds to diagnose early synovitis [ Time Frame: 1 day ]
|Study Start Date:||September 2005|
|Study Completion Date:||May 2009|
|Primary Completion Date:||April 2008 (Final data collection date for primary outcome measure)|
Procedure: Power Doppler Sonography
Aim #1 - To determine if PDS can be used to diagnose synovial hypertrophy and inflammation in joint disease associated with inherited bleeding disorders. MRI will be used as a reference standard.
Aim #2 - To determine if PDS can be used to assess therapeutic response to treatment.
Aim #3 - To determine if PDS can be used as a screening tool for diagnosing early synovitis.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00212485
|United States, New York|
|New York Presbyterian Hospital/Hospital for Special Surgery|
|New York, New York, United States, 10021|
|Principal Investigator:||Suchitra S Acharya, MD||Weill Medical College of Cornell University|