Functional Magnetic Resonance Imaging (fMRI) Studies in Pathological Gambling (PG) and Obsessive-Compulsive Disorder (OCD)
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ClinicalTrials.gov Identifier: NCT00211822
Recruitment Status :
(Enrollments closed after former PI Eric Hollander left institution. There are no results.)
This study will explore the brain processes associated with inhibition and reward processing in pathological gamblers and people with obsessive compulsive disorder compared to healthy controls. Healthy participants and participants who are diagnosed with PG or OCD will undergo one fMRI scan. The brain scan will last about one and a half hours and will involve performing tasks while in the scanner.
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Ages Eligible for Study:
18 Years to 55 Years (Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Male or female adults diagnosed with pathological gambling or obsessive compulsive disorder aged 18-55.
Subject has signed an informed consent form
Must provide contact information
Must be in generally good health
Must be willing and able to read written instructions and complete scales
Must be English speaking
In the opinion of the investigator, the subject is capable of complying with all study procedures
Pathological Gamblers only:
Current diagnosis of pathological gambling, supported by DSM-IV SCI-PG
Must score ≥ 5 on SOGS
Must score ≥ 2 on item number 1 on the G-SAS
Subjects must have a severity score of ≥ 4 (moderately ill) on the Clinical Global Impressions Scale - Severity (CGI-S)
Must score ≥ 10 on questions 1-5 on PG-Y-BOCS
Must score ≤ 15 on YMRS
Must have gambled once within past 2 weeks of Screening Visit.
Subjects with a primary diagnosis of schizophrenia, personality disorder, or other psychotic disorders
Subjects with a primary diagnosis of an Axis I disorder that may require intervention
Must not score >24 on the Montgomery-Asberg Depression Rating Scale (MADRS) (pathological gamblers only)
Subjects who live in a restrictive environment
Subjects with a current DSM-IV diagnosis of substance dependence or abuse, excluding nicotine
Subjects reporting a history of drug and/or alcohol dependence or abuse; subjects who report occasional drug use in the past will be discussed by a panel (consisting of Dr. Gilbert, Dr. Fan and Dr. Bartz), and will be considered for participation on a case by case basis
Subjects who have used psychotropic medications in the past week to six weeks (depending on the medication)
Subject has a positive drug urine screen
Female subjects who are pregnant
Subjects who report a history of severe liver, heart, or kidney disease because these conditions are associated with neurological sequella
Employees of the investigator or study center or their families
Finally, subjects who do not satisfy the following criteria will be excluded because they will be unable to undergo the MRI procedure. Specifically, subjects will be excluded who have:
any implanted metallic chips in their head
ever worked around a metal lathe or had a shrapnel (war or gun shot) wound/injury
an implanted neuro-stimulatory or infusion/insulin pump