Trial record 9 of 73 for:    "Asperger syndrome"

Functional Magnetic Resonance Imaging (fMRI) for the Study of Response Inhibition, and Face and Linguistic Processing in Autism

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00211783
Recruitment Status : Completed
First Posted : September 21, 2005
Last Update Posted : June 28, 2012
Information provided by (Responsible Party):
Icahn School of Medicine at Mount Sinai

Brief Summary:
This study investigates face processing, response inhibition and phoneme processing in autistic adults by fMRI.

Condition or disease Intervention/treatment
Autism Asperger's Syndrome Procedure: fMRI

Detailed Description:
Fifteen adult outpatients with high functioning autism or Asperger's Syndrome will be recruited. Fifteen healthy volunteers matched for age and IQ will also be recruited. Participants will undergo an fMRI scan. During the scan they will perform a task. The paradigm is designed to test control inhibition, face processing and language. Therefore, it includes a go-no go test, a face emotion discrimination test and a linguistic sound. The subjects are shown a series of faces with happy or sad expressions in random order. Each face presentation is accompanied by either a standard or variant sound. The sound stimulus is the English phoneme /oe/. The variant sound was created by raising the frequency of the standard sound by 20%. The task consists of four blocks. During each block the subjects are asked to press a button when they see a happy or sad face depending on the block. Each block consists of 96 trials lasting 2 seconds and an initial and final fixation period of 40 sec. For each trial the target image is projected for 500 ms. There is 1250 ms fixation time allowed for response and 250 ms for jitter. Twenty-four of the 96 trials are no go trials and 16/96 are sound oddball trials. The oddball is at least two trials apart (between two variant sounds there are at least two standard sounds). There are 24 faces displayed in total, 12 female and 12 male. Faces switch every 16 trials. Face genders are balanced. The faces were selected with over 80% congruency except for two faces with congruency of over 72%. The correlation between sound (2 conditions: standard versus variant) and target condition (go-no go) is zero. The task was piloted on healthy controls and autistic adults. All subjects performed well.

Study Type : Observational
Actual Enrollment : 71 participants
Observational Model: Case Control
Time Perspective: Prospective
Official Title: fMRI for the Study of Response Inhibition, and Face and Linguistic Processing in Autism
Study Start Date : November 2004
Actual Primary Completion Date : November 2011
Actual Study Completion Date : June 2012

Group/Cohort Intervention/treatment
Autism Procedure: fMRI
there is no intervention


Primary Outcome Measures :
  1. BOLD [ Time Frame: at single study visit ]
    Differences in BOLD betweens controls and ASD group BOLD - blood-oxygen-level-dependent contrast

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 50 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Thirty adults with ASD and 30

Inclusion Criteria:

  • Age range of 18-50 years old
  • Diagnosis: autism spectrum disorder by Diagnostic and Statistical Manual of Mental Disorders, 4th Edition (DSM-IV) and Autism Diagnostic Interview - Revised (ADI-R)
  • Intelligence quotient (IQ) > 80
  • Outpatients

Exclusion Criteria:

  • Subjects with epilepsy
  • Subjects with history of schizophrenia, schizoaffective disorder or other Axis 1 mental disorders, such as bipolar disorder
  • Subjects reporting history of encephalitis, phenylketonuria, tuberous sclerosis, fragile X syndrome, anoxia during birth, neurofibromatosis, hypomelanosis of Ito, hypothyroidism, Duchenne muscular dystrophy, and maternal rubella
  • Subjects who have received depot neuroleptic medication, or other psychoactive drugs within the past 5 weeks.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00211783

United States, New York
Mount Sinai School of Medicine
New York, New York, United States, 10029
Sponsors and Collaborators
Icahn School of Medicine at Mount Sinai
Principal Investigator: Evdokia Anagnostou Icahn School of Medicine at Mount Sinai

Responsible Party: Icahn School of Medicine at Mount Sinai Identifier: NCT00211783     History of Changes
Other Study ID Numbers: GCO# 04-0749
First Posted: September 21, 2005    Key Record Dates
Last Update Posted: June 28, 2012
Last Verified: June 2012

Keywords provided by Icahn School of Medicine at Mount Sinai:
response inhibition
face processing
linguistic processing

Additional relevant MeSH terms:
Autistic Disorder
Asperger Syndrome
Child Development Disorders, Pervasive
Neurodevelopmental Disorders
Mental Disorders