Intraoperative Nitrous Oxide and Postoperative Pain for Patients With Current Opioid Treatment (PROTOX)
Peroperative opioids are known to induce N-Methyl-D-Aspartate dependent enhancement of postoperative hyperalgesia. For patients with current opioid treatment, these phenomena could be exagerated and could produce greater postoperative opioid consumption and higher pain score. Since Nitrous oxide has anti- N-Methyl-D-Aspartate properties, the aim of this study was to evaluate, in patients with current opioid treatment, the effects of peroperative Nitous oxide on postoperative opioid consumption and pain score, after vertebroplasty.
|Study Design:||Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Primary Purpose: Treatment
|Official Title:||Effects of Intraoperative Nitrous Oxide on Postoperative Pain for Patients With Current Opioid Treatment After Vertebroplasty.|
- Visual Analogue Scale (VAS) and morphine consumption recorded for 48 postoperative hours (every 8 hours).
- Preoperative and postoperative pressure pain threshold (pressure algometer)
|Study Start Date:||January 2005|
|Study Completion Date:||December 2006|
Please refer to this study by its ClinicalTrials.gov identifier: NCT00210158
|Institut Bergonié - Centre Régional de Luttre Contre le Cancer DE Bordeaux et du Sud Ouest|
|Bordeaux, France, 33076|
|Principal Investigator:||Fabrice LAKDJA, MD||Institut Bergonié - Centre Régional de Luttre Contre le Cancer de Bordeaux et du Sud Ouest|