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Fear Potentiation and Fear Inhibition in Posttraumatic Stress Disorder

This study is ongoing, but not recruiting participants.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00209040
First Posted: September 21, 2005
Last Update Posted: November 23, 2016
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
Erica Duncan, MD, Emory University
  Purpose
The current study will investigate the ability of people with and without fear symptoms after trauma to inhibit fear in an experimental situation.

Condition Intervention
Posttraumatic Stress Disorder Procedure: acoustic startle testing

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Fear Potentiation and Fear Inhibition in Posttraumatic Stress Disorder

Resource links provided by NLM:


Further study details as provided by Erica Duncan, MD, Emory University:

Primary Outcome Measures:
  • fear potentiation of acoustic startle [ Time Frame: baseline ]
    percent change in acoustic startle magnitude during visual cue conditioned to aversive stimuli, compared to trials without aversive sitmuli


Estimated Enrollment: 250
Study Start Date: January 2001
Estimated Study Completion Date: January 2018
Estimated Primary Completion Date: December 2017 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
1
Subjects with posttraumatic stress disorder
Procedure: acoustic startle testing
See protocol description for methodological details
2
Healthy controls
Procedure: acoustic startle testing
See protocol description for methodological details
3
Combat controls
Procedure: acoustic startle testing
See protocol description for methodological details

  Show Detailed Description

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 80 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
see protocol description
Criteria

Inclusion Criteria:

  • Age 18-80
  • Diagnosis of PTSD
  • Healthy controls (no history of PTSD)
  • Combat controls (no history of PTSD)

Exclusion Criteria:

  • No drug or alcohol abuse or dependence
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00209040


Locations
United States, Georgia
Atlanta VA Medical Center
Decatur, Georgia, United States, 30033
Sponsors and Collaborators
Emory University
Investigators
Principal Investigator: Erica Duncan, MD Emory University/Atlanta VA Medical Center
  More Information

Responsible Party: Erica Duncan, MD, Associate Professor, Emory University
ClinicalTrials.gov Identifier: NCT00209040     History of Changes
Other Study ID Numbers: IRB00000983
First Submitted: September 14, 2005
First Posted: September 21, 2005
Last Update Posted: November 23, 2016
Last Verified: November 2016

Keywords provided by Erica Duncan, MD, Emory University:
PTSD
Acoustic startle

Additional relevant MeSH terms:
Disease
Stress Disorders, Traumatic
Stress Disorders, Post-Traumatic
Pathologic Processes
Trauma and Stressor Related Disorders
Mental Disorders


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