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Muscle Relaxation Therapy With Odorant Cue

This study has been completed.
Information provided by:
Emory University Identifier:
First received: September 13, 2005
Last updated: November 8, 2013
Last verified: November 2013
A novel procedure for generalized anxiety disorder where an odorant cue is paired with the state of deep relaxation during training. It is hypothesized that by smelling the odor in an anxiety-provoking situation, the patient will more easily invoke a state of relaxation, providing greater relief from the distressing tension and worry that characterize GAD.

Condition Intervention
Generalized Anxiety Disorder Anxiety Behavioral: Odorant Cue

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: Single
Primary Purpose: Treatment
Official Title: A Study of Enhancement of Progressive Muscle Relaxation Therapy for Generalized Anxiety Disorder Through Use Of An Odorant Cue.

Resource links provided by NLM:

Further study details as provided by Emory University:

Primary Outcome Measures:
  • PSWQ

Secondary Outcome Measures:
  • HAM-A

Estimated Enrollment: 15
Study Start Date: November 2003
Estimated Study Completion Date: May 2005
Detailed Description:
We hypothesize that by presenting a novel odor to a patient in a state of deep relaxation, the odor will serve as a conditioned inhibitory stimulus, or safety signal, in anxiety-provoking situations. With the odor serving as a contextual cue for the state of relaxation.

Ages Eligible for Study:   18 Years to 65 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • GAD without a comorbid active major psychiatric disorder.
  • GAD must be the primary active psychiatric disorder.
  • GAD determined via the Mini International Neuropsychiatric Interview (MINI).

Exclusion Criteria:

  • Significant medical illness that might interfere with the relaxation therapy or with training using the odorant.
  • Actively abusing alcohol.
  • Illicit substances.
  • Currently using rapid-acting anxiolytic agents (e.g. benzodiazepines, hydroxyzine).
  • Started an antidepressant, antipsychotic or mood stabilizing agent within three months of screening visit.
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Please refer to this study by its identifier: NCT00208910

United States, Georgia
Emory University School of Medicine
Atlanta, Georgia, United States, 30329
Sponsors and Collaborators
Emory University
Principal Investigator: Philip T Ninan, MD Emory University
  More Information Identifier: NCT00208910     History of Changes
Other Study ID Numbers: 0860-2003
Study First Received: September 13, 2005
Last Updated: November 8, 2013

Keywords provided by Emory University:
Mental Health

Additional relevant MeSH terms:
Anxiety Disorders
Mental Disorders processed this record on September 19, 2017