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A Randomised Multi-centre Study to Compare the Long-term Performance of the Future Hip to 3 Other Implants in Primary Total Hip Replacement

This study has been terminated.
(Slow recruitment, investigators not wishing to continue with randomisation and a decision to rationalise this product from the Sponsors portfolio.)
Sponsor:
Information provided by (Responsible Party):
DePuy International
ClinicalTrials.gov Identifier:
NCT00208468
First received: September 13, 2005
Last updated: October 6, 2016
Last verified: October 2016
  Purpose
This post-market clinical follow-up study was designed to compare hip replacement outcomes of the European Hip against 3 controls (Omniflex, Zweymuller, and Spotorno), however Omniflex did not end up being used. The first patient had surgery on February 18, 2000 and the final patient had surgery on September 2, 2005. There were 317 subjects consented but only 301 had hip replacement surgery (subjects received: 220 European hips, 33 Zweymuller, and 48 Spotorno). The study took place at three sites. Each site used their standard device as the control. The Austrian site enrolled 69 European hips and 33 Zweymuller hips. 92 European hips and 48 Spotorno hips were enrolled in Germany. Finally, the site in Italy enrolled 59 European hips. Although the study protocol intended collecting DEXA and RSA outcomes, the data collected by the sites did not include these outcomes.

Condition Intervention Phase
Osteoarthritis
Post-traumatic Arthritis
Collagen Disorders
Avascular Necrosis
Traumatic Femoral Fractures
Nonunion of Femoral Fractures
Congenital Hip Dysplasia
Slipped Capital Femoral Epiphysis
Perthes Disease
Device: European Hip
Device: Zweymüller
Device: CLS Spotorno
Phase 3

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: A Multi-centre, Randomised, Parallel Group, Controlled Study to Compare the Performance of the Future Hip Against Three Currently Used Implants in Total Hip Replacement

Resource links provided by NLM:


Further study details as provided by DePuy International:

Primary Outcome Measures:
  • To Compare Survivorship estimates between subjects receiving the European, Spotorno, and Zweymuller hip devices through the 2 year follow-up period. [ Time Frame: 2yrs post-surgery ] [ Designated as safety issue: Yes ]
    Kaplan Meier survivorship analysis estimates the proportion of a population that will survive past a certain time avoiding a certain event. In this study, the event is removal of any component for any reason, also known as revision for any reason.


Secondary Outcome Measures:
  • Implant survivorship at 5 and 10 years. [ Time Frame: 5 & 10 year post-op ] [ Designated as safety issue: Yes ]
    This post market study was terminated early; therefore the 5 and 10 year data was not collected.

  • To Compare Harris Hip Scores between subjects receiving the European, Spotorno, and Zweymuller hip devices. [ Time Frame: 3 Months post-op ] [ Designated as safety issue: No ]
    The Harris Hip score is a 0-100 point score (where 100 indicates excellent hip condition) assessing pain, function, range of motion, and absence of deformity, of the affected hip.

  • To Compare Harris Hip scores between subjects receiving the European, Spotorno, and Zweymuller hip devices [ Time Frame: 6 Months post-op ] [ Designated as safety issue: No ]
    The Harris Hip score is a 0-100 point score (where 100 indicates excellent hip condition) assessing pain, function, range of motion, and absence of deformity, of the affected hip.

  • To Compare Harris Hip Scores between subjects receiving the European, Spotorno, and Zweymuller hip devices [ Time Frame: 12 months post-op ] [ Designated as safety issue: No ]
    The Harris Hip score is a 0-100 point score (where 100 indicates excellent hip condition) assessing pain, function, range of motion, and absence of deformity, of the affected hip.

  • To Compare Harris Hip scores between subjects receiving the European, Spotorno, and Zweymuller hip devices [ Time Frame: 24 months post-op ] [ Designated as safety issue: No ]
    The Harris Hip Score is a 0-100 point score (where 100 indicates excellent hip condition) assessing pain, function, range of motion, and absence of deformity, of the affected hip.

  • To Compare Harris Hip Scores between subjects receiving the European, Spotorno, and Zweymuller hip devices [ Time Frame: 5 & 10 years post-op ] [ Designated as safety issue: No ]
    This post market study was terminated early; therefore the 5 and 10 year data was not collected

  • To Compare Oxford Hip Scores between subjects receiving the European, Spotorno, and Zweymuller hip devices [ Time Frame: 3 months post-op ] [ Designated as safety issue: No ]
    The Oxford Knee Score (OKS) is a 12 to 60 patient recorded outcome (PRO) score (where 12 indicates the best outcome) that evaluates pain and function of the affected hip.

  • To Compare Oxford Hip Scores between subjects receiving the European, Spotorno, and Zweymuller hip devices [ Time Frame: 6 months post-op ] [ Designated as safety issue: No ]
    The Oxford Knee Score (OKS) is a 12 to 60 patient recorded outcome (PRO) score (where 12 indicates the best outcome) that evaluates pain and function of the affected hip.

  • To Compare Oxford Hip Scores between subjects receiving the European, Spotorno, and Zweymuller hip devices [ Time Frame: 12 months post-op ] [ Designated as safety issue: No ]
    The Oxford Knee Score (OKS) is a 12 to 60 patient recorded outcome (PRO) score (where 12 indicates the best outcome) that evaluates pain and function of the affected hip.

  • To Compare Oxford Hip Scores between subjects receiving the European, Spotorno, and Zweymuller hip devices [ Time Frame: 24 months post-op ] [ Designated as safety issue: No ]
    he Oxford Knee Score (OKS) is a 12 to 60 patient recorded outcome (PRO) score (where 12 indicates the best outcome) that evaluates pain and function of the affected hip.

  • To Compare Oxford Hip Scores between subjects receiving the European, Spotorno, and Zweymuller hip devices [ Time Frame: 5& 10 years post-op ] [ Designated as safety issue: No ]
    This post market study was terminated early; therefore the 5 & 10 year data was not collected

  • Progressive Radiolucent Zone(s) - Femur: To compare Progressive Radiolucent Zone(s) incidence between subjects receiving the European, Spotorno, and Zweymuller hip devices [ Time Frame: 3 months post-op ] [ Designated as safety issue: No ]
    Width of lucency increases over time or expands lengthwise (into neighboring zones).

  • Progressive Radiolucent Zone(s) - Femur: To compare Progressive Radiolucent Zone(s) incidence between subjects receiving the European, Spotorno, and Zweymuller hip devices [ Time Frame: 6 months post-op ] [ Designated as safety issue: No ]
    Width of lucency increases over time or expands lengthwise (into neighboring zones).

  • Progressive Radiolucent Zone(s) - Femur: To compare Progressive Radiolucent Zone(s) incidence between subjects receiving the European, Spotorno, and Zweymuller hip devices [ Time Frame: 12 months post-op ] [ Designated as safety issue: No ]
    Width of lucency increases over time or expands lengthwise (into neighboring zones).

  • Progressive Radiolucent Zone(s) - Femur: To compare Progressive Radiolucent Zone(s) incidence between subjects receiving the European, Spotorno, and Zweymuller hip devices [ Time Frame: 24 months post-op ] [ Designated as safety issue: No ]
    Width of lucency increases over time or expands lengthwise (into neighboring zones).

  • Progressive Radiolucent Zone(s) - Femur: To compare Progressive Radiolucent Zone(s) incidence between subjects receiving the European, Spotorno, and Zweymuller hip devices [ Time Frame: 5 & 10 years post-op ] [ Designated as safety issue: No ]
    This post market study was terminated early; therefore the 5 & 10 year data was not collected

  • Progressive Radiolucent Zone(s) - Acetabulum: To compare Progressive Radiolucent Zone(s) incidence between subjects receiving the European, Spotorno, and Zweymuller hip devices [ Time Frame: 3 months post-op ] [ Designated as safety issue: No ]
    Width of lucency increases over time or expands lengthwise (into neighboring zones).

  • Progressive Radiolucent Zone(s) - Acetabulum: To compare Progressive Radiolucent Zone(s) incidence between subjects receiving the European, Spotorno, and Zweymuller hip devices [ Time Frame: 6 month post-op ] [ Designated as safety issue: No ]
    Width of lucency increases over time or expands lengthwise (into neighboring zones).

  • Progressive Radiolucent Zone(s) - Acetabulum: To compare Progressive Radiolucent Zone(s) incidence between subjects receiving the European, Spotorno, and Zweymuller hip devices [ Time Frame: 12 months post-op ] [ Designated as safety issue: No ]
    Width of lucency increases over time or expands lengthwise (into neighboring zones).

  • Progressive Radiolucent Zone(s) - Acetabulum: To compare Progressive Radiolucent Zone(s) incidence between subjects receiving the European, Spotorno, and Zweymuller hip devices [ Time Frame: 24 months post-op ] [ Designated as safety issue: No ]
    Width of lucency increases over time or expands lengthwise (into neighboring zones).

  • Progressive Radiolucent Zone(s) - Acetabulum: To compare Progressive Radiolucent Zone(s) incidence between subjects receiving the European, Spotorno, and Zweymuller hip devices [ Time Frame: 5 & 10 year post-op ] [ Designated as safety issue: No ]
    This post-market study was terminated early; therefore the 5 & 10 year data was not collected

  • Migration - Femoral: To compare Progressive Migration incidence between subjects receiving the European, Spotorno, and Zweymuller hip devices [ Time Frame: 3 months post-op ] [ Designated as safety issue: No ]
    Component moves away, continuously over time, from its immediate post-operative position.

  • Migration - Femoral: To compare Progressive Migration incidence between subjects receiving the European, Spotorno, and Zweymuller hip devices [ Time Frame: 6 months post-op ] [ Designated as safety issue: No ]
    Component moves away, continuously over time, from its immediate post-operative position.

  • Migration - Femoral: To compare Progressive Migration incidence between subjects receiving the European, Spotorno, and Zweymuller hip devices [ Time Frame: 12 months post-op ] [ Designated as safety issue: No ]
    Component moves away, continuously over time, from its immediate post-operative position.

  • Migration - Femoral: To compare Progressive Migration incidence between subjects receiving the European, Spotorno, and Zweymuller hip devices [ Time Frame: 24 months post-op ] [ Designated as safety issue: No ]
    Component moves away, continuously over time, from its immediate post-operative position.

  • Migration - Femoral: To compare Progressive Migration incidence between subjects receiving the European, Spotorno, and Zweymuller hip devices [ Time Frame: 5 & 10 years post-op ] [ Designated as safety issue: No ]
    This study was terminated early; therefore the 5 & 10 year data was not collected

  • Migration - Acetabular: To compare Progressive Migration between subjects receiving the European, Spotorno, and Zweymuller hip devices [ Time Frame: 3 months post-op ] [ Designated as safety issue: No ]
    Component moves away, continuously over time, from its immediate post-operative position.

  • Migration - Acetabular: To compare Progressive Migration between subjects receiving the European, Spotorno, and Zweymuller hip devices [ Time Frame: 6 months post-op ] [ Designated as safety issue: No ]
    Component moves away, continuously over time, from its immediate post-operative position.

  • Migration - Acetabular: To compare Progressive Migration between subjects receiving the European, Spotorno, and Zweymuller hip devices [ Time Frame: 12 months post-op ] [ Designated as safety issue: No ]
    Component moves away, continuously over time, from its immediate post-operative position.

  • Migration - Acetabular: To compare Progressive Migration between subjects receiving the European, Spotorno, and Zweymuller hip devices [ Time Frame: 24 months post-op ] [ Designated as safety issue: No ]
    Component moves away, continuously over time, from its immediate post-operative position

  • Migration - Acetabular: To compare Progressive Migration between subjects receiving the European, Spotorno, and Zweymuller hip devices [ Time Frame: 5 & 10 years post-op ] [ Designated as safety issue: No ]
    This post market study was terminated early; therefore the 5 & 10 year data was not collected

  • Progressive Osteolysis - Femur: To compare Progressive Osteolysis incidence between subjects receiving the European, Spotorno, and Zweymuller hip devices [ Time Frame: 3 months post-op ] [ Designated as safety issue: No ]
    Component moves away, continuously over time, from its immediate post-operative position.

  • Progressive Osteolysis - Femur: To compare Progressive Osteolysis incidence between subjects receiving the European, Spotorno, and Zweymuller hip devices [ Time Frame: 6 months post-op ] [ Designated as safety issue: No ]
    Component moves away, continuously over time, from its immediate post-operative position

  • Progressive Osteolysis - Femur: To compare Progressive Osteolysis incidence between subjects receiving the European, Spotorno, and Zweymuller hip devices [ Time Frame: 12 months post-op ] [ Designated as safety issue: No ]
    Component moves away, continuously over time, from its immediate post-operative position.

  • Progressive Osteolysis - Femur: To compare Progressive Osteolysis incidence between subjects receiving the European, Spotorno, and Zweymuller hip devices [ Time Frame: 24 months post-op ] [ Designated as safety issue: No ]
    Component moves away, continuously over time, from its immediate post-operative position.

  • Progressive Osteolysis - Femur: To compare Progressive Osteolysis incidence between subjects receiving the European, Spotorno, and Zweymuller hip devices [ Time Frame: 5 & 10 years post-op ] [ Designated as safety issue: No ]
    This post market study was terminated early; therefore the 5 & 10 year data was not collected

  • Progressive Osteolysis - Acetabulum: To compare Progressive Osteolysis incidence between subjects receiving the European, Spotorno, and Zweymuller hip devices [ Time Frame: 3 months post-op ] [ Designated as safety issue: No ]
    Component moves away, continuously over time, from its immediate post-operative position.

  • Progressive Osteolysis - Acetabulum: To compare Progressive Osteolysis incidence between subjects receiving the European, Spotorno, and Zweymuller hip devices [ Time Frame: 6 months post-op ] [ Designated as safety issue: No ]
    Component moves away, continuously over time, from its immediate post-operative position.

  • Progressive Osteolysis - Acetabulum: To compare Progressive Osteolysis incidence between subjects receiving the European, Spotorno, and Zweymuller hip devices [ Time Frame: 12 months post-op ] [ Designated as safety issue: No ]
    Component moves away, continuously over time, from its immediate post-operative position

  • Progressive Osteolysis - Acetabulum: To compare Progressive Osteolysis incidence between subjects receiving the European, Spotorno, and Zweymuller hip devices [ Time Frame: 24 months post-op ] [ Designated as safety issue: No ]
    Component moves away, continuously over time, from its immediate post-operative position

  • Progressive Osteolysis - Acetabulum: To compare Progressive Osteolysis incidence between subjects receiving the European, Spotorno, and Zweymuller hip devices [ Time Frame: 5 & 10 years post-op ] [ Designated as safety issue: No ]
    This post market study was terminated early; therefore the 5 & 10 year data was not collected

  • Trochanteric Non-Union - Femur: To compare Trochanteric Non-union incidence between subjects receiving the European, Spotorno, and Zweymuller hip devices [ Time Frame: 3 months post-op ] [ Designated as safety issue: No ]
    Trochanter portion of the bone does not heal correctly to proximal portion of the femoral shaft. Typically, after 6 months the lack of correct healing is classified as a 'non-union'.

  • Trochanteric Non-Union - Femur: To compare Trochanteric Non-union incidence between subjects receiving the European, Spotorno, and Zweymuller hip devices [ Time Frame: 6 months post-op ] [ Designated as safety issue: No ]
    Trochanter portion of the bone does not heal correctly to proximal portion of the femoral shaft. Typically, after 6 months the lack of correct healing is classified as a 'non-union'

  • Trochanteric Non-Union - Femur: To compare Trochanteric Non-union incidence between subjects receiving the European, Spotorno, and Zweymuller hip devices [ Time Frame: 12 months post-op ] [ Designated as safety issue: No ]
    Trochanter portion of the bone does not heal correctly to proximal portion of the femoral shaft. Typically, after 6 months the lack of correct healing is classified as a 'non-union'.

  • Trochanteric Non-Union - Femur: To compare Trochanteric Non-union incidence between subjects receiving the European, Spotorno, and Zweymuller hip devices [ Time Frame: 24 months post-op ] [ Designated as safety issue: No ]
    Trochanter portion of the bone does not heal correctly to proximal portion of the femoral shaft. Typically, after 6 months the lack of correct healing is classified as a 'non-union'.

  • Trochanteric Non-Union - Femur: To compare Trochanteric Non-union incidence between subjects receiving the European, Spotorno, and Zweymuller hip devices [ Time Frame: 5 & 10 years post-op ] [ Designated as safety issue: No ]
    This post market study was terminated early; therefore the 5 & 10 year data was not collected

  • To compare Femoral Stem Orientation between subjects receiving the European, Spotorno, and Zweymuller hip devices. [ Time Frame: 3 months post-op ] [ Designated as safety issue: No ]
    Alignment is classified into 1 of 3 categories - Neutral, Varus (distal tip of stem lateral to mid-line of femur), or Valgus (distal tip of stem medial to mid-line of femur).

  • To compare Femoral Stem Orientation between subjects receiving the European, Spotorno, and Zweymuller hip devices. [ Time Frame: 6 months post-op ] [ Designated as safety issue: No ]
    Alignment is classified into 1 of 3 categories - Neutral, Varus (distal tip of stem lateral to mid-line of femur), or Valgus (distal tip of stem medial to mid-line of femur).

  • To compare Femoral Stem Orientation between subjects receiving the European, Spotorno, and Zweymuller hip devices. [ Time Frame: 12 months post-op ] [ Designated as safety issue: No ]
    Alignment is classified into 1 of 3 categories - Neutral, Varus (distal tip of stem lateral to mid-line of femur), or Valgus (distal tip of stem medial to mid-line of femur).

  • To compare Femoral Stem Orientation between subjects receiving the European, Spotorno, and Zweymuller hip devices. [ Time Frame: 24 months post-op ] [ Designated as safety issue: No ]
    Alignment is classified into 1 of 3 categories - Neutral, Varus (distal tip of stem lateral to mid-line of femur), or Valgus (distal tip of stem medial to mid-line of femur).

  • To compare Femoral Stem Orientation between subjects receiving the European, Spotorno, and Zweymuller hip devices. [ Time Frame: 5 & 10 years post-op ] [ Designated as safety issue: No ]
    This post market study was terminated early; therefore the 5 & 10 year data was not collected

  • To compare Brooker Ectopic Ossification between subjects receiving the European, Spotorno, and Zweymuller hip devices. [ Time Frame: 3 months post-op ] [ Designated as safety issue: No ]
    Presented by Brooker in JBJS 55a: 1629-1632 (1973). Soft tissue or bone bridging causing immobilization in severe cases; categorized into classes I to IV with I being islands of bone around soft tissue, and IV representing ankylosis of the hip.

  • To compare Brooker Ectopic Ossification between subjects receiving the European, Spotorno, and Zweymuller hip devices. [ Time Frame: 6 months post-op ] [ Designated as safety issue: No ]
    Presented by Brooker in JBJS 55a: 1629-1632 (1973). Soft tissue or bone bridging causing immobilization in severe cases; categorized into classes I to IV with I being islands of bone around soft tissue, and IV representing ankylosis of the hip.

  • To compare Brooker Ectopic Ossification between subjects receiving the European, Spotorno, and Zweymuller hip devices. [ Time Frame: 12 months post-op ] [ Designated as safety issue: No ]
    Presented by Brooker in JBJS 55a: 1629-1632 (1973). Soft tissue or bone bridging causing immobilization in severe cases; categorized into classes I to IV with I being islands of bone around soft tissue, and IV representing ankylosis of the hip.

  • To compare Brooker Ectopic Ossification between subjects receiving the European, Spotorno, and Zweymuller hip devices. [ Time Frame: 24 months post-op ] [ Designated as safety issue: No ]
    Presented by Brooker in JBJS 55a: 1629-1632 (1973). Soft tissue or bone bridging causing immobilization in severe cases; categorized into classes I to IV with I being islands of bone around soft tissue, and IV representing ankylosis of the hip.

  • To compare Brooker Ectopic Ossification between subjects receiving the European, Spotorno, and Zweymuller hip devices. [ Time Frame: 5 & 10 years post-op ] [ Designated as safety issue: No ]
    This post market study was terminated early; therefore the 5 & 10 year data was not collected

  • To compare Acetabular Socket Wear between subjects receiving the European, Spotorno, and Zweymuller hip devices [ Time Frame: 3 months post-op ] [ Designated as safety issue: No ]
    Linear wear, measured in millimeters (mm) of the femoral head into the acetabular socket.

  • To compare Acetabular Socket Wear between subjects receiving the European, Spotorno, and Zweymuller hip devices [ Time Frame: 6 months post-op ] [ Designated as safety issue: No ]
    Linear wear, measured in millimeters (mm) of the femoral head into the acetabular socket.

  • To compare Acetabular Socket Wear between subjects receiving the European, Spotorno, and Zweymuller hip devices [ Time Frame: 12 months post-op ] [ Designated as safety issue: No ]
    Linear wear, measured in millimeters (mm) of the femoral head into the acetabular socket

  • To compare Acetabular Socket Wear between subjects receiving the European, Spotorno, and Zweymuller hip devices [ Time Frame: 24 months post-op ] [ Designated as safety issue: No ]
    Linear wear, measured in millimeters (mm) of the femoral head into the acetabular socket.

  • To compare Acetabular Socket Wear between subjects receiving the European, Spotorno, and Zweymuller hip devices [ Time Frame: 5 & 10 years post-op ] [ Designated as safety issue: No ]
    This post market study was terminated early; therefore the 5 & 10 year data was not collected


Enrollment: 317
Study Start Date: February 2000
Study Completion Date: March 2015
Primary Completion Date: June 2005 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
European Hip
A cementless femoral component for use in total hip replacement
Device: European Hip
A cementless femoral component for use in total hip replacement
Active Comparator: Zweymüller
A cementless femoral component for use in total hip replacement
Device: Zweymüller
A cementless femoral component for use in total hip replacement
Active Comparator: CLS Spotorno
A cementless femoral component for use in total hip replacement
Device: CLS Spotorno
A cementless femoral component for use in total hip replacement

  Eligibility

Ages Eligible for Study:   55 Years to 75 Years   (Adult, Senior)
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

i) Administrative - The subject is able to understand the study, is willing to give voluntary, written, informed consent, will co-operate with assessment procedures and is geographically able to comply with the post-operative follow-up regime.

ii) Age - The subject's age is between 18 and 75 years inclusive.

iii) Sex - Male or female subjects may be recruited to the study.

iv) Diagnosis -Subjects must be undergoing primary THR surgery for non-inflammatory degenerative joint disease including osteoarthritis, avascular necrosis, post-traumatic arthritis, fractured neck of femur and non-union of fractured neck of femur, SUFE or Perthes disease.

v) Suitability - Subjects who in the opinion of the Investigator are considered to be suitable for treatment with the devices involved in the study.

Exclusion Criteria:

i) Subjects undergoing revision procedure to the operative hip.

ii) Subjects who have had a previous femoral osteotomy to the operative hip.

iii) Subjects who have a history of active sepsis in the joint.

iv) Subjects who have been diagnosed with primary or secondary carcinomas in the last five years (excluding basal cell carcinoma or cervical carcinoma).

v) Subjects with any condition which may, in the opinion of the Investigator, interfere with the total hip replacement's survival or outcome, e.g. Paget's disease, Charcot's disease.

vi) Subjects with psycho-social disorders which, in the opinion of the Investigator would limit rehabilitation.

vii) Subject's whose weight is > 100kg.

viii) Subjects with femoral head necrosis on the non-operated side (RSA and DEXA subjects only).

ix) Subjects who have a fracture of the femur > 6 months old (RSA and DEXA subjects only).

x) Subjects diagnosed as having ankylosing spondylitis (RSA and DEXA subjects only)

xi) Subjects with a known history of poor compliance to medical treatment.

  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00208468

Locations
Austria
Univ. Kliniken
Graz, Austria
Germany
Univesitätsklinikum Jena
Eisenberg, Germany
Italy
InstitutoAzienda Gaetano Pini
Milan, Italy
Sponsors and Collaborators
DePuy International
  More Information

Responsible Party: DePuy International
ClinicalTrials.gov Identifier: NCT00208468     History of Changes
Other Study ID Numbers: CT99/02 
Study First Received: September 13, 2005
Last Updated: October 6, 2016
Health Authority: Austria: Federal Ministry for Health and Women

Keywords provided by DePuy International:
Hip
Cementless

Additional relevant MeSH terms:
Osteoarthritis
Fractures, Bone
Necrosis
Femoral Fractures
Legg-Calve-Perthes Disease
Slipped Capital Femoral Epiphyses
Collagen Diseases
Rheumatic Diseases
Hip Dislocation, Congenital
Hip Dislocation
Arthritis
Joint Diseases
Musculoskeletal Diseases
Wounds and Injuries
Pathologic Processes
Leg Injuries
Femur Head Necrosis
Osteonecrosis
Bone Diseases
Osteochondrodysplasias
Bone Diseases, Developmental
Epiphyses, Slipped
Connective Tissue Diseases
Musculoskeletal Abnormalities
Congenital Abnormalities
Dislocations
Hip Injuries

ClinicalTrials.gov processed this record on December 02, 2016