A Study of the Safety and Efficacy of Infliximab (Remicade) in Subjects With Fistulizing Crohn's Disease
|ClinicalTrials.gov Identifier: NCT00207766|
Recruitment Status : Completed
First Posted : September 21, 2005
Last Update Posted : April 27, 2010
|Condition or disease||Intervention/treatment||Phase|
|Crohn Disease||Drug: infliximab or placebo||Phase 3|
This is a medical research study for patients with Crohn's disease who have one or more draining enterocutaneous fistula (fistula from the bowel to the skin). Fistulas are a common complication of Crohn's disease. Fistulas rarely close spontaneously but they may get better with treatment of the underlying Crohn's disease. This study will investigate the safety and efficacy of maintenance dosing of an anti-TNF (anti-tumor necrosis factor) antibody (a protein), called infliximab, compared to a placebo (inactive substance) in providing sustained reductions in the number of draining fistulas.
Subjects will receive infliximab at weeks 0, 2 and 6 followed by infusions of infliximab 5 mg/kg or placebo at weeks 14 and every 8 weeks until week 46. Patients who lose response are eligible for increasing treatment by 5 mg/kg of infliximab.
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||306 participants|
|Intervention Model:||Parallel Assignment|
|Official Title:||ACCENT II - A Randomized, Double-blind, Placebo-controlled Trial of Anti-TNF Chimeric Monoclonal Antibody (Infliximab, Remicade) in the Long Term Treatment of Patients With Fistulizing CROHN'S Disease|
|Study Start Date :||June 2000|
|Study Completion Date :||August 2006|
- Reduction in the number of draining fistulas
- Complete fistula response (no draining fistula).
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00207766
|Study Director:||Centocor, Inc. Clinical Trial||Centocor, Inc.|