Airway IgA: Respiratory Tract IgA Levels in Critically Ill Intubated Patients

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00205309
Recruitment Status : Completed
First Posted : September 20, 2005
Last Update Posted : October 18, 2012
Information provided by (Responsible Party):
University of Wisconsin, Madison

Brief Summary:
This study will examine the impact of acute illness on sequential airway IgA levels in intensive care patients who will require prolonged intubation. Infections are the most common cause of late deaths in non-head injured trauma patients and a frequent cause of morbidity and mortality in hospitalized patients, especially intubated Intensive Care Unit (ICU) patients. Nosocomial pneumonia is the most common of these infections, and its incidence in defined populations of critically injured patients is responsive to route and type of nutrition. This study will focus on the mechanisms of specific immune mucosal defenses in intestinal and extraintestinal sites and link enteral feeding (or lack of it) with maintenance (or deterioration) of respiratory mucosal defenses.

Condition or disease
Intubation Critically Ill

Study Type : Observational
Actual Enrollment : 13 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Respiratory Tract IgA Levels in Critically Ill Intubated Patients
Study Start Date : January 2003
Actual Primary Completion Date : June 2011
Actual Study Completion Date : June 2011

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Intubated intensive care patients

Inclusion Criteria:

  • Subjects must be intubated, intensive care patients.

Exclusion Criteria:

  • No severe pulmonary contusions or evidence of airway bleeding

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00205309

United States, Wisconsin
University of Wisconsin Hospital and Clinics
Madison, Wisconsin, United States, 53792
Sponsors and Collaborators
University of Wisconsin, Madison
Principal Investigator: Kenneth Kudsk, MD University of Wisconsin Medical School

Responsible Party: University of Wisconsin, Madison Identifier: NCT00205309     History of Changes
Other Study ID Numbers: 2002-562
First Posted: September 20, 2005    Key Record Dates
Last Update Posted: October 18, 2012
Last Verified: October 2012

Keywords provided by University of Wisconsin, Madison:
intubated patients

Additional relevant MeSH terms:
Critical Illness
Disease Attributes
Pathologic Processes