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Airway IgA: Respiratory Tract IgA Levels in Critically Ill Intubated Patients

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00205309
First Posted: September 20, 2005
Last Update Posted: October 18, 2012
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
University of Wisconsin, Madison
  Purpose
This study will examine the impact of acute illness on sequential airway IgA levels in intensive care patients who will require prolonged intubation. Infections are the most common cause of late deaths in non-head injured trauma patients and a frequent cause of morbidity and mortality in hospitalized patients, especially intubated Intensive Care Unit (ICU) patients. Nosocomial pneumonia is the most common of these infections, and its incidence in defined populations of critically injured patients is responsive to route and type of nutrition. This study will focus on the mechanisms of specific immune mucosal defenses in intestinal and extraintestinal sites and link enteral feeding (or lack of it) with maintenance (or deterioration) of respiratory mucosal defenses.

Condition
Intubation Critically Ill

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Respiratory Tract IgA Levels in Critically Ill Intubated Patients

Further study details as provided by University of Wisconsin, Madison:

Enrollment: 13
Study Start Date: January 2003
Study Completion Date: June 2011
Primary Completion Date: June 2011 (Final data collection date for primary outcome measure)
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Intubated intensive care patients
Criteria

Inclusion Criteria:

  • Subjects must be intubated, intensive care patients.

Exclusion Criteria:

  • No severe pulmonary contusions or evidence of airway bleeding
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00205309


Locations
United States, Wisconsin
University of Wisconsin Hospital and Clinics
Madison, Wisconsin, United States, 53792
Sponsors and Collaborators
University of Wisconsin, Madison
Investigators
Principal Investigator: Kenneth Kudsk, MD University of Wisconsin Medical School
  More Information

Responsible Party: University of Wisconsin, Madison
ClinicalTrials.gov Identifier: NCT00205309     History of Changes
Other Study ID Numbers: 2002-562
First Submitted: September 13, 2005
First Posted: September 20, 2005
Last Update Posted: October 18, 2012
Last Verified: October 2012

Keywords provided by University of Wisconsin, Madison:
intubated patients

Additional relevant MeSH terms:
Critical Illness
Disease Attributes
Pathologic Processes