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Airway IgA: Respiratory Tract IgA Levels in Critically Ill Intubated Patients

This study has been completed.
Information provided by (Responsible Party):
University of Wisconsin, Madison Identifier:
First received: September 13, 2005
Last updated: October 16, 2012
Last verified: October 2012
This study will examine the impact of acute illness on sequential airway IgA levels in intensive care patients who will require prolonged intubation. Infections are the most common cause of late deaths in non-head injured trauma patients and a frequent cause of morbidity and mortality in hospitalized patients, especially intubated Intensive Care Unit (ICU) patients. Nosocomial pneumonia is the most common of these infections, and its incidence in defined populations of critically injured patients is responsive to route and type of nutrition. This study will focus on the mechanisms of specific immune mucosal defenses in intestinal and extraintestinal sites and link enteral feeding (or lack of it) with maintenance (or deterioration) of respiratory mucosal defenses.

Critically Ill

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Respiratory Tract IgA Levels in Critically Ill Intubated Patients

Resource links provided by NLM:

Further study details as provided by University of Wisconsin, Madison:

Enrollment: 13
Study Start Date: January 2003
Study Completion Date: June 2011
Primary Completion Date: June 2011 (Final data collection date for primary outcome measure)

Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Intubated intensive care patients

Inclusion Criteria:

  • Subjects must be intubated, intensive care patients.

Exclusion Criteria:

  • No severe pulmonary contusions or evidence of airway bleeding
  Contacts and Locations
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Please refer to this study by its identifier: NCT00205309

United States, Wisconsin
University of Wisconsin Hospital and Clinics
Madison, Wisconsin, United States, 53792
Sponsors and Collaborators
University of Wisconsin, Madison
Principal Investigator: Kenneth Kudsk, MD University of Wisconsin Medical School
  More Information

Responsible Party: University of Wisconsin, Madison Identifier: NCT00205309     History of Changes
Other Study ID Numbers: 2002-562
Study First Received: September 13, 2005
Last Updated: October 16, 2012

Keywords provided by University of Wisconsin, Madison:
intubated patients

Additional relevant MeSH terms:
Critical Illness
Disease Attributes
Pathologic Processes processed this record on May 25, 2017