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Cardiac Water and Fluoromethane Cardiac PET

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00205127
First Posted: September 20, 2005
Last Update Posted: August 29, 2012
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
University of Wisconsin, Madison
  Purpose
In this study we are looking at the blood flow to the heart using two different chemical tags or tracers that give off a low level of radiation. The tracers used in this study are called O15-water and F17-fluoromethane. These tracers mix with the blood and will move through the body. The researchers will use positron emission tomography (PET scans)to track the tracers as they moe through the heart and chest.

Condition Intervention
Healthy Volunteers Procedure: Cardiac PET imaging- rest and pharmacological stress

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Diagnostic
Official Title: Comparison of Cardiac Perfusion by O15-water and F17-fluoromethane PET

Resource links provided by NLM:


Further study details as provided by University of Wisconsin, Madison:

Primary Outcome Measures:
  • -- implement myocardial perfusion quantification for O15-labeled water at rest and with pharmacologic stress, [ Time Frame: assess at time of PET scan ]
  • -- determine the biodistribution of fluoromethane in the thorax to see if it is usable for a cardiac perfusion tracer, [ Time Frame: assess at time of PET Scan ]

Secondary Outcome Measures:
  • --develop initial methods for quantification of myocardial perfusion if applicable for labeled fluoromethane. [ Time Frame: assess at time of PET scan ]

Estimated Enrollment: 10
Study Start Date: January 2004
Study Completion Date: March 2004
Primary Completion Date: March 2004 (Final data collection date for primary outcome measure)
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 40 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • 1. Age 18 to 40 years old 2. Willing to provide written informed consent

Exclusion Criteria:

  • 1. A history of CAD 2. A history of active bronchospasm or asthma on theophylline bronchodilators 3. A history of any cardiac risk factors including: HTN, Diabetes, Hyperlipidemia, Smoking, and premature CAD in immediate family member 4. A history of liver disease or other significant disease 5. Females who are pregnant or lactating
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00205127


Locations
United States, Wisconsin
University of Wisconsin
Madison, Wisconsin, United States, 53792
Sponsors and Collaborators
University of Wisconsin, Madison
Investigators
Principal Investigator: Charles K Stone, MD Univeristy of Wisconsin
  More Information

Responsible Party: University of Wisconsin, Madison
ClinicalTrials.gov Identifier: NCT00205127     History of Changes
Other Study ID Numbers: 2003-241
First Submitted: September 12, 2005
First Posted: September 20, 2005
Last Update Posted: August 29, 2012
Last Verified: August 2012

Keywords provided by University of Wisconsin, Madison:
Cardiac PET imaging
Radiopharmaceutical tracers