Childhood Origins of Asthma (COAST) (COAST)

This study is ongoing, but not recruiting participants.

Sponsor:

Collaborators:

National Institutes of Health (NIH)

National Heart, Lung, and Blood Institute (NHLBI)

Information provided by (Responsible Party):

University of Wisconsin, Madison

ClinicalTrials.gov Identifier:

NCT00204841

First received: September 12, 2005

Last updated: November 24, 2015

Last verified: November 2015

History of Changes

Purpose

Although asthma is likely to be a heterogeneous disease or syndrome, three factors and/or events repetitively emerge for their ability to significantly influence asthma inception in the first decade of life: immune response aberrations, which appear to be defined best by the concept of cytokine dysregulation; lower respiratory tract infections (in particular RSV); and some form of gene by environment interaction that needs to occur at a critical time period in the development of the immune system or the lung. It remains to be firmly established, however, how any one or all of these factors, either independently or interactively, influence the development of childhood asthma. Thus, our efforts to determine and define the importance of these three factors to asthma pathogenesis are the focus and goal of this current grant application.

Condition
Asthma Allergy


Study Type:	Observational
Study Design:	Observational Model: Cohort Time Perspective: Prospective
Official Title:	Rhinovirus Infection and Asthma in Childhood and Adolescents

Further study details as provided by University of Wisconsin, Madison:

Primary Outcome Measures:

Evaluate the children longitudinally for the inception and progression of asthma. [ Time Frame: Birth through puberty. ] [ Designated as safety issue: No ]

Biospecimen Retention: Samples With DNA

nasal mucus samples, cord blood, peripheral blood samples, nasal cell brushing samples, cell lines


Estimated Enrollment:	300
Study Start Date:	October 1998
Estimated Study Completion Date:	May 2018
Estimated Primary Completion Date:	May 2018 (Final data collection date for primary outcome measure)

Detailed Description:

No more description necessary.

Eligibility


Ages Eligible for Study:	up to 2 Minutes (Child)
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No
Sampling Method:	Non-Probability Sample

Study Population

High risk birth cohort of children (one or both parents have allergies and/or asthma).

Criteria

Inclusion Criteria:

children who had one or more parent with a history of allergy or asthma

Exclusion Criteria:

pre term infants
low birth weight infants
respiratory distress at birth

Contacts and Locations

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00204841

Locations


United States, Wisconsin
University of Wisconsin
Madison, Wisconsin, United States, 53792

Sponsors and Collaborators

University of Wisconsin, Madison

National Institutes of Health (NIH)

National Heart, Lung, and Blood Institute (NHLBI)

Investigators


Principal Investigator:	Robert F Lemanske, Jr., MD	University of Wisconsin, Madison

More Information


Responsible Party:	University of Wisconsin, Madison
ClinicalTrials.gov Identifier:	NCT00204841 History of Changes
Other Study ID Numbers:	1998-129 P01HL070831
Study First Received:	September 12, 2005
Last Updated:	November 24, 2015
Health Authority:	United States: Food and Drug Administration

Additional relevant MeSH terms:


Asthma Bronchial Diseases Respiratory Tract Diseases Lung Diseases, Obstructive Lung Diseases	Respiratory Hypersensitivity Hypersensitivity, Immediate Hypersensitivity Immune System Diseases

ClinicalTrials.gov processed this record on September 28, 2016

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