Childhood Origins of Asthma (COAST) (COAST)

Study Description

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Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

Brief Summary:

Although asthma is likely to be a heterogeneous disease or syndrome, three factors and/or events repetitively emerge for their ability to significantly influence asthma inception in the first decade of life: immune response aberrations, which appear to be defined best by the concept of cytokine dysregulation; lower respiratory tract infections (in particular RSV); and some form of gene by environment interaction that needs to occur at a critical time period in the development of the immune system or the lung. It remains to be firmly established, however, how any one or all of these factors, either independently or interactively, influence the development of childhood asthma. Thus, our efforts to determine and define the importance of these three factors to asthma pathogenesis are the focus and goal of this current grant application.

Condition or disease
Asthma; Allergy

Detailed Description:

No more description necessary.

Study Design

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Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

Study Type :	Observational
Estimated Enrollment :	300 participants
Observational Model:	Cohort
Time Perspective:	Prospective
Official Title:	Rhinovirus Infection and Asthma in Childhood and Adolescents
Study Start Date :	October 1998
Estimated Primary Completion Date :	May 2018
Estimated Study Completion Date :	May 2018

Groups and Cohorts

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Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

Outcome Measures

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Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

Primary Outcome Measures :

1. Evaluate the children longitudinally for the inception and progression of asthma. [ Time Frame: Birth through puberty. ]

Biospecimen Retention:   Samples With DNA

nasal mucus samples, cord blood, peripheral blood samples, nasal cell brushing samples, cell lines

Eligibility Criteria

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Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

Ages Eligible for Study:	up to 2 Minutes (Child)
Sexes Eligible for Study:	All
Accepts Healthy Volunteers:	No
Sampling Method:	Non-Probability Sample

Study Population

High risk birth cohort of children (one or both parents have allergies and/or asthma).

Criteria

Inclusion Criteria:

• children who had one or more parent with a history of allergy or asthma

Exclusion Criteria:

• pre term infants
• low birth weight infants
• respiratory distress at birth

Contacts and Locations

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Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

Locations

United States, Wisconsin
University of Wisconsin
Madison, Wisconsin, United States, 53792

Sponsors and Collaborators

University of Wisconsin, Madison

National Institutes of Health (NIH)

National Heart, Lung, and Blood Institute (NHLBI)

Investigators

Principal Investigator:	Robert F Lemanske, Jr., MD	University of Wisconsin, Madison

More Information

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Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

Responsible Party:	University of Wisconsin, Madison
ClinicalTrials.gov Identifier:	NCT00204841 History of Changes
Other Study ID Numbers:	1998-129; P01HL070831 ( U.S. NIH Grant/Contract )
First Posted:	September 20, 2005
Last Update Posted:	March 31, 2017
Last Verified:	March 2017

Additional relevant MeSH terms:

Asthma; Bronchial Diseases; Respiratory Tract Diseases; Lung Diseases, Obstructive; Lung Diseases	Respiratory Hypersensitivity; Hypersensitivity, Immediate; Hypersensitivity; Immune System Diseases