Childhood Origins of Asthma (COAST)
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Purpose
Although asthma is likely to be a heterogeneous disease or syndrome, three factors and/or events repetitively emerge for their ability to significantly influence asthma inception in the first decade of life: immune response aberrations, which appear to be defined best by the concept of cytokine dysregulation; lower respiratory tract infections (in particular RSV); and some form of gene by environment interaction that needs to occur at a critical time period in the development of the immune system or the lung. It remains to be firmly established, however, how any one or all of these factors, either independently or interactively, influence the development of childhood asthma. Thus, our efforts to determine and define the importance of these three factors to asthma pathogenesis are the focus and goal of this current grant application.
| Condition |
|---|
|
Asthma Allergy |
| Study Type: | Observational |
| Study Design: | Observational Model: Cohort Time Perspective: Prospective |
| Official Title: | Rhinovirus Infection and Asthma in Childhood and Adolescents |
- Evaluate the children longitudinally for the inception and progression of asthma. [ Time Frame: Birth through puberty. ] [ Designated as safety issue: No ]
Biospecimen Retention: Samples With DNA
nasal mucus samples, cord blood, peripheral blood samples, nasal cell brushing samples, cell lines
| Estimated Enrollment: | 300 |
| Study Start Date: | October 1998 |
| Estimated Study Completion Date: | May 2018 |
| Estimated Primary Completion Date: | May 2018 (Final data collection date for primary outcome measure) |
No more description necessary.
Eligibility| Ages Eligible for Study: | up to 2 Minutes |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
| Sampling Method: | Non-Probability Sample |
High risk birth cohort of children (one or both parents have allergies and/or asthma).
Inclusion Criteria:
- children who had one or more parent with a history of allergy or asthma
Exclusion Criteria:
- pre term infants
- low birth weight infants
- respiratory distress at birth
Contacts and LocationsPlease refer to this study by its ClinicalTrials.gov identifier: NCT00204841
| United States, Wisconsin | |
| University of Wisconsin | |
| Madison, Wisconsin, United States, 53792 | |
| Principal Investigator: | Robert F Lemanske, Jr., MD | University of Wisconsin, Madison |
More Information
Additional Information:
No publications provided
| Responsible Party: | University of Wisconsin, Madison |
| ClinicalTrials.gov Identifier: | NCT00204841 History of Changes |
| Other Study ID Numbers: | 1998-129, P01HL070831 |
| Study First Received: | September 12, 2005 |
| Last Updated: | December 1, 2014 |
| Health Authority: | United States: Food and Drug Administration |
Additional relevant MeSH terms:
|
Asthma Bronchial Diseases Hypersensitivity Hypersensitivity, Immediate Immune System Diseases |
Lung Diseases Lung Diseases, Obstructive Respiratory Hypersensitivity Respiratory Tract Diseases |
ClinicalTrials.gov processed this record on March 01, 2015