Childhood Origins of Asthma (COAST)

This study is ongoing, but not recruiting participants.
Information provided by (Responsible Party):
University of Wisconsin, Madison Identifier:
First received: September 12, 2005
Last updated: December 1, 2014
Last verified: December 2014

Although asthma is likely to be a heterogeneous disease or syndrome, three factors and/or events repetitively emerge for their ability to significantly influence asthma inception in the first decade of life: immune response aberrations, which appear to be defined best by the concept of cytokine dysregulation; lower respiratory tract infections (in particular RSV); and some form of gene by environment interaction that needs to occur at a critical time period in the development of the immune system or the lung. It remains to be firmly established, however, how any one or all of these factors, either independently or interactively, influence the development of childhood asthma. Thus, our efforts to determine and define the importance of these three factors to asthma pathogenesis are the focus and goal of this current grant application.


Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Rhinovirus Infection and Asthma in Childhood and Adolescents

Further study details as provided by University of Wisconsin, Madison:

Primary Outcome Measures:
  • Evaluate the children longitudinally for the inception and progression of asthma. [ Time Frame: Birth through puberty. ] [ Designated as safety issue: No ]

Biospecimen Retention:   Samples With DNA

nasal mucus samples, cord blood, peripheral blood samples, nasal cell brushing samples, cell lines

Estimated Enrollment: 300
Study Start Date: October 1998
Estimated Study Completion Date: May 2018
Estimated Primary Completion Date: May 2018 (Final data collection date for primary outcome measure)
Detailed Description:

No more description necessary.


Ages Eligible for Study:   up to 2 Minutes
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population

High risk birth cohort of children (one or both parents have allergies and/or asthma).


Inclusion Criteria:

  • children who had one or more parent with a history of allergy or asthma

Exclusion Criteria:

  • pre term infants
  • low birth weight infants
  • respiratory distress at birth
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Please refer to this study by its identifier: NCT00204841

United States, Wisconsin
University of Wisconsin
Madison, Wisconsin, United States, 53792
Sponsors and Collaborators
University of Wisconsin, Madison
Principal Investigator: Robert F Lemanske, Jr., MD University of Wisconsin, Madison
  More Information

Additional Information:
No publications provided

Responsible Party: University of Wisconsin, Madison Identifier: NCT00204841     History of Changes
Other Study ID Numbers: 1998-129, P01HL070831
Study First Received: September 12, 2005
Last Updated: December 1, 2014
Health Authority: United States: Food and Drug Administration processed this record on March 26, 2015