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Effects of Anemia Correction on Vascular and Monocyte Function in Renal Transplant Recipients

This study has been completed.
Information provided by:
University Hospital Muenster Identifier:
First received: September 12, 2005
Last updated: January 12, 2010
Last verified: May 2008

Correction of anaemia in renal transplant recipients by parenteral application of recombinant erythropoietin and if necessary iron will improve large artery function (endothelial function and elasticity), as assessed by ultrasound techniques and applanation tonometry.

The changes in large artery function will be reflected by changes in serological markers of endothelial function and oxidative stress and by changes in monocyte function and apoptosis.

There are gender differences in the responses of vascular function to correction of anemia.

Besides improvement of large artery function, correction of anemia will also affect parameters of graft function, i.e. glomerular and tubular proteinuria.

Condition Intervention Phase
Kidney Transplantation Anemia Drug: darbopoeitin Phase 4

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: Effects of Anemia Correction on Vascular Function, Endothelial Cell Markers and Monocyte Apoptosis in Renal Transplant Recipients

Resource links provided by NLM:

Further study details as provided by University Hospital Muenster:

Primary Outcome Measures:
  • Vessel wall stiffness

Secondary Outcome Measures:
  • expression of endothelial cell markers

Estimated Enrollment: 60
Study Start Date: June 2005
Study Completion Date: January 2010
Primary Completion Date: January 2010 (Final data collection date for primary outcome measure)
  Show Detailed Description


Ages Eligible for Study:   18 Years to 75 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

kidney transplant recipient stable kidney function Hb between 10mg/ml and 10.5mg/ml

Exclusion Criteria:

acute rejection Hb above 12.0mg/dl

  Contacts and Locations
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Please refer to this study by its identifier: NCT00204334

Münster, NRW, Germany, 48149
Sponsors and Collaborators
University Hospital Muenster
Principal Investigator: Martin Hausberg, MD UKM- Medical Department D
  More Information

Responsible Party: University Hospital Muenster Identifier: NCT00204334     History of Changes
Other Study ID Numbers: Haus_Lang-Endothel-Mono-Hb
Study First Received: September 12, 2005
Last Updated: January 12, 2010

Keywords provided by University Hospital Muenster:
Kidney transplantation
vascular endothelium

Additional relevant MeSH terms:
Hematologic Diseases processed this record on August 23, 2017