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Monitoring of Intubation and Ventilation During Resuscitation

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ClinicalTrials.gov Identifier: NCT00204217
Recruitment Status : Completed
First Posted : September 20, 2005
Last Update Posted : August 27, 2007
Information provided by:

Study Description
Brief Summary:
Airway control and ventilation is vital during cardiopulmonary resuscitation (CPR) in cardiac arrest. Endotracheal intubation is the gold standard for airway control, but several studies have shown high rates of unrecognized placements of the tube in the esophagus instead of in the airway out-of-hospital. This is lethal. There are no failproof technique for recognising such mistakes clinically in the cardiac arrest situation. Changes on the air volume in the lungs with ventilation changes the impedance (resistance to alternating current) through the thorax. This impedance is already measured routinely by the defibrillators used during CPR. We propose that we can measure ventilation volumes and also discover failed intubations by monitoring this impedance during CPR with the possibility of giving feedback on both to the rescuers.

Condition or disease Intervention/treatment Phase
Cardiac Arrest Device: endotracheal intubation Phase 2

Detailed Description:
On the anesthesiologist manned ambulance in Oslo ventilation volumes during CPR will be controlled with a ventilator, the tidal volume varied in random order between 500, 700 and 100 ml, and the volumes be measured continuously as will the impedance between the defibrillator electrodes. In case of failed CPR, the patient will be declared dead. Thereafter the lungs will be ventilated with 700 ml followed by removal of the endotracheal tube, placement of an endotracheal tube in the esophagus and ventilation of this tube, again with monitoring of the impedance.

Study Design

Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 15 participants
Allocation: Non-Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)
Primary Purpose: Diagnostic
Official Title: Monitoring of Intubation and Ventilation During Resuscitation
Study Start Date : September 2004
Study Completion Date : April 2007

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Cardiac Arrest
U.S. FDA Resources

Arms and Interventions

Outcome Measures

Primary Outcome Measures :
  1. sensitivity/specificity for lung ventilation detection
  2. correlation ventilation volume - impedance change

Eligibility Criteria

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Cardiac arrest

Exclusion Criteria:

  • <18 years old trauma pregnancy
Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00204217

Ulleval University Hospital
Oslo, Norway, N-0407
Sponsors and Collaborators
University of Oslo
Laerdal Medical
Ullevaal University Hospital
Health Region East, Norway
Norwegian Air Ambulance Foundation
University of Stavanger
Principal Investigator: Elizabeth Dorph Ulleval University Hospital, University of Oslo
More Information

ClinicalTrials.gov Identifier: NCT00204217     History of Changes
Other Study ID Numbers: 313-04124
First Posted: September 20, 2005    Key Record Dates
Last Update Posted: August 27, 2007
Last Verified: August 2007

Keywords provided by University of Oslo:
cardiac arrest

Additional relevant MeSH terms:
Heart Arrest
Heart Diseases
Cardiovascular Diseases