The Role of Reactive Oxygen Species in Ischaemia-Reperfusion Injury of the Transplanted Kidney
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|ClinicalTrials.gov Identifier: NCT00204178|
Recruitment Status : Unknown
Verified August 2005 by Uniwersytet Mikolaja Kopernika w Toruniu.
Recruitment status was: Active, not recruiting
First Posted : September 20, 2005
Last Update Posted : December 1, 2005
|Condition or disease||Intervention/treatment|
|Kidney Transplantation||Behavioral: Oxidative stress in kidney transplant recipients|
Oxidative stress is one of the most important factors in ischaemia-reperfusion injury to the transplanted organ. In kidney transplant recipients following factors were measured: glutathione level, activities of glutathione peroxidase (GSH-PX), catalase (CAT) and superoxide dismutase (SOD) and superoxide anion production by granulocytes in whole blood without and after the stimulation with zymosan.
Blood was sampled from peripheral vein (before reperfusion) and directly from renal vein (5 and 15 minutes after reperfusion).
Transplanted kidney function was evaluated by the incidence and length of Delayed Graft Function and serum creatinine level in 2 and 6 weeks after transplantation.
|Study Type :||Observational|
|Estimated Enrollment :||60 participants|
|Observational Model:||Defined Population|
|Observational Model:||Natural History|
|Official Title:||The Role of Reactive Oxygen Species in Ischaemia-Reperfusion Injury of the Transplanted Kidney|
|Study Start Date :||April 2003|
|Estimated Study Completion Date :||September 2005|
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00204178
|Klinika Transplantologii, Szpital Uniwersytecki, ul. M. Sklodowskiej-Curie 9|
|Bydgoszcz, Poland, 85-094|
|Study Director:||Zbigniew Wlodarczyk, MD,PhD||Klinika Transplantologii Collegium Medicum UMK w Toruniu|