Exercise and Prevention of Syncope: EXPOSE
The purpose of this study is to determine whether eight weeks of exercise performed at an intensity of approximately 65% VO2max will improve symptoms associated with fainting (vasovagal syncope).
Device: Blood volume
Procedure: VO2max test
Procedure: Lower body negative pressure
Behavioral: Heart Rate
Procedure: Blood Pressure
Behavioral: Total Peripheral Resistance
|Study Design:||Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Single Blind
Primary Purpose: Treatment
|Official Title:||EXercise for the Prevention of Syncope Evaluation|
- Orthostatic tolerance - this will be measured at baseline and post intervention
|Study Start Date:||March 2006|
|Estimated Study Completion Date:||June 2007|
Background: Vasovagal syncope affects 20-30% of the population, and for those who faint recurrently it causes a significant reduction in the quality of life. Although significant progress has been made in the past 15 years in our understanding of its diagnosis and prognosis, our therapeutic attempts often end in failure. Many patients who have been diagnosed with vasovagal syncope have a reduced orthostatic tolerance. Improved orthostatic tolerance has been achieved through exercise in a number of studies on healthy individuals. However, its efficacy as a means of treatment for those with vasovagal syncope has not been thoroughly explored.
Comparison: Subjects will be randomized to one of two groups: an exercise group or control. The exercise group will be asked to train at a target of approximately 65% of their maximum exercise capacity (VO2max) for 8 weeks/3 times per week. The control group will be asked to perform a series of neck rotation exercises. Orthostatic tolerance will be examined in both groups pre and post intervention.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00203593
|University of Calgary (Health Sciences Center)|
|Calgary, Alberta, Canada, T2N 4N1|
|Principal Investigator:||Robert S Sheldon, MD PhD||University of Calgary|