A Clinical Study of An Antimicrobial Gauze Dressing
|Study Design:||Allocation: Randomized
Intervention Model: Parallel Assignment
Primary Purpose: Prevention
|Official Title:||A Prospective Randomized Double-Blind Trial of a Polyhexamethylene Biguanide (PHMB) Impregnated Gauze Dressing for the Prevention of Chronic Wound Colonization With Resistant and Prevalent Microorganisms|
- Rate of chronic wound colonization with resistant/prevalent microorganisms.
- Rate of wound surface area healing over time; Antibiotic utilization.
|Study Start Date:||June 2005|
|Estimated Study Completion Date:||August 2007|
Without adequate debridement, chronically infected wounds persist and form a nidus for the acquisition of antimicrobial-resistant microorganisms. Multiple studies state that patients with chronic wounds were colonized with one or more resistant bacteria, and that the presence of a chronic wound or decubitus ulcer was associated with a statistically increased likelihood of colonization with methicillin-resistant Staphylococcus aureus (MRSA), ciprofloxacin-resistant gram-negative bacilli (GNB),colonization and infection with ceftazidime-resistant Escherichia coli and Klebsiella pneumoniae.
Recently, a newly formulated gauze dressing impregnated with an antiseptic agent has become available. This product offers the promise of a combined benefit of wet-to-dry mechanical debridement, while providing high local concentrations of a potent antiseptic to prevent colonization and infection of the wound by resistant microorganisms, potentially enhancing wound healing.
This study proposes to determine if use of the antimicrobial gauze in routine wound care results in a lower rate of chronic wound colonization with resistant microorganisms and prevalent microorganisms as compared to standard wound care (with non-antimicrobial gauze).
Please refer to this study by its ClinicalTrials.gov identifier: NCT00203489
|Sunnybrook & Women's College Health Sciences Centre|
|Toronto, Ontario, Canada, M5S 1B2|
|Study Director:||Tonya M. Eggleston, RN, MPH||Tyco Healthcare/Kendall|