TNF-Alpha Inhibition for Treatment of Alzheimer's Disease
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government.
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It is widely believed that inflammation contributes to the pathogenesis of AD. TNF has been implicated in both AD and neurological inflammation. Anti-TNF therapy is therefore surmised to be of potential benefit for treating AD.
Condition or disease
Drug: etanercept given by perispinal administration
Etanercept, a biologic anti-TNF fusion protein, will be administered weekly or biweekly by perispinal injection to a maximum of 15 study subjects for a period of one month, followed by a 5 month and a 6 month possible study extension, with serial testing of cognition and function monthly.
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Ages Eligible for Study:
Child, Adult, Senior
Sexes Eligible for Study:
Accepts Healthy Volunteers:
NINCDS-ADRDA Criteria for Alzheimer’s disease
CT or MRI consistent with AD
uncontrolled diabetes mellitus
clinically significant neurologic disease other than AD
history of lymphoma
premenopausal, fertile not on acceptable birth control
change in neuroactive medication within 4 weeks of study initiation