Choline Quantification in Breast Cancer by MRS
|ClinicalTrials.gov Identifier: NCT00201487|
Recruitment Status : Withdrawn (We chose to use an exsisting NMR pulse sequence already established and available at the hospital.)
First Posted : September 20, 2005
Last Update Posted : October 31, 2013
Choline has been found in increased concentration in breast cancer patients. Hypothesis: The choline signal as observed by MRS is sensitive to treatment, and a positive response to treatment will give a reduction in choline concentration.
The purpose of this study is to establish methods for quantification of choline in breast cancer by MRS
|Condition or disease|
- Establishment of new MRS sequence for choline quantification of choline. This sequence is choline-selective, and signals from water and lipids are suppressed simultaneously.
- Compare to different methods for choline quantification. The first method is quantification through an external phantom standard, containing a known concentration of choline. The other method is based on the utilisation of internal water signal as a reference.
Both calculations can be performed from the same MR exam. Ten patients will be included in the study.
|Study Type :||Observational|
|Actual Enrollment :||0 participants|
|Official Title:||Choline Quantification in Breast Cancer by MRS|
|Study Start Date :||November 2007|
|Primary Completion Date :||November 2007|
|Study Completion Date :||November 2007|
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00201487
|Principal Investigator:||Tone Bathen, PhD||NTNU, Faculty of medicine,|