Acute, Affective, Organic Disorders.
|Study Design:||Observational Model: Case Control
Time Perspective: Prospective
|Official Title:||Signs of Organic Brain Dysfunction in Psychiatric Patients With Fluctuating Psychiatric Symptoms Including Brief Depressions Compared to Patients With a Major Depressive Episode.|
- epilepsy or an other organic brain disorder [ Time Frame: 1 week ]EEG and QEEG are taken three times in the first week
Biospecimen Retention: Samples Without DNA
|Study Start Date:||October 1998|
|Study Completion Date:||June 2010|
|Primary Completion Date:||October 2004 (Final data collection date for primary outcome measure)|
brief depressive periods
brief depressive periods together with other fluctuating psychiatric symptoms
|major depressive disorder|
A limited number of patients admitted to psychiatric acute wards or Psychiatric Intensive Care Units are admitted with a fluctuating array of psychiatric symptoms including brief depressive episodes. These patients do not fit into the present diagnostic systems due to short duration of affective symptoms and the fluctuating arrays of other symptoms. Case histories indicate that these patients have psychiatric conditions due to epilepsy or organic brain dysfunctions.
In the study acutely admitted patients filling criteria for two recent DSM-4 axis 1 diagnoses (one is a brief depressive period) during the last two weeks are compared to age- and sex-matched patients acutely admitted with a major depressive disorder. The patients are rated with a number of rating scales at admittance, day 5, after two weeks and three months. EEG and QEEG are taken three times the first week. MRI, drug screening and blood screening of medication-concentrations are taken.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00201474
|Østmarka Psychiatric Department, St. Olavs Hospital|
|Trondheim, Norway, 7441|
|Study Chair:||Olav M Linaker, Professor||Norwegian University of Science and Technology|