Identifying the Anti-Blood-Clotting Compounds in Garlic
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|ClinicalTrials.gov Identifier: NCT00200785|
Recruitment Status : Completed
First Posted : September 20, 2005
Results First Posted : January 11, 2010
Last Update Posted : January 11, 2010
|Condition or disease||Intervention/treatment||Phase|
|Arteriosclerosis Intracranial Arteriosclerosis||Dietary Supplement: garlic powder added to ambient water Dietary Supplement: garlic powder added to boiling water||Not Applicable|
Published studies indicate that various types of undefined garlic products display antiplatelet activity. However, the compounds responsible for this antiplatelet effect have not been identified.
Acute studies. In acute (one day) studies, healthy participants will consume several doses of "fresh garlic" (garlic powder added to ambient water; up to the equivalent of 12 grams fresh garlic or 52 mg allicin) as a paste in a tuna sandwich. At 0, 2, 4, and 6 hours after consumption, the ability of platelets to aggregate in platelet-rich plasma (PRP) or in whole blood (WB), in response to a drug (collagen, ADP) that stimulates platelet aggregation, will be measured. After establishing the optimum dose and optimum time of the antiplatelet effect for each person, and if the effects are sufficiently strong, the effects of cooked garlic (garlic powder added to boiling water, no allicin present) and seven extracted fractions (oil, protein, fructans, etc.) will be determined, using the fractions at the same dose as their abundance in the established optimum dose of crushed fresh garlic.
Chronic studies. If only weak platelet effects are found for a high acute dose of "fresh" garlic, chronic studies will be conducted. In chronic studies, participants will consume 8.0 grams of "fresh garlic" (2.7 grams garlic powder added to ambient water, allicin content = 35 mg) as a paste in a tuna sandwich every day for four weeks and 8.0 grams of "boiled garlic" (2.7 grams garlic powder added to boiling water) in a sandwich every day for an additional four weeks, after a 1-week washout. The ability of platelets to aggregate in PRP and whole blood will be determined before and every week after garlic consumption begins and after the 1-week washout.
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||9 participants|
|Intervention Model:||Crossover Assignment|
|Masking:||None (Open Label)|
|Official Title:||Identification of the Antiplatelet Compounds of Garlic Ex Vivo|
|Study Start Date :||March 2006|
|Actual Primary Completion Date :||September 2007|
|Actual Study Completion Date :||September 2007|
Active Comparator: Garlic powder in ambient water
Dietary Supplement: garlic powder added to ambient water
consumed 2.7 grams of garlic powder added to ambient water (equivalent to 8 grams fresh or raw garlic) in a sandwich, once a day for four weeks
Other Name: Global Marketing Assoc., Inc.
Experimental: garlic powder in boiling water
Dietary Supplement: garlic powder added to boiling water
consumed 2.7 grams of garlic powder added to boiling water (equivalent to 8 grams of cooked garlic) in a sandwich, once a day for four weeks
Other Name: Global Marketing Assoc., Inc.
- Percent Platelet Aggregation [ Time Frame: 4 weeks ]percent platelet aggregation in collagen-induced platelet aggregation in platelet rich plasma (PRP)
- Electrical Impedance in Ohms [ Time Frame: 4 weeks ]Electrical impedance (ohms) was measured using 0.5 mL of whole blood plus 0.5 mL saline in a Chronolog Whole Blood aggregometer. Ten mL of whole blood were collected and tested every week. There is no mathematical correlation between impedance (ohms) and percent aggregation.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00200785
|United States, Utah|
|Silliker, Inc./Plant Bioactives Research Institute|
|Orem, Utah, United States, 84058|
|Principal Investigator:||Larry D. Lawson, PhD||Silliker, Inc./Plant Bioactives Research Institute|