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Lactic Acid in the Rectum and Life-Threatening Infection

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00197938
First Posted: September 20, 2005
Last Update Posted: June 9, 2009
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
Herlev Hospital
  Purpose

Life-threatening infection impairs bloodflow to the gut, thereby causing less delivery of oxygen. This leads to increased formation of lactic acid.

The investigators hypothesize, that the more serious the condition, the higher the concentration of lactic acid will be, thus relating to the risk of multiple organ failure or death.


Condition Intervention
Septic Shock Procedure: Measurement of rectal lactic acid.

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Does the Concentration of L-Lactate in the Rectum Correlate With Mortality and Morbidity in Patients With Septic Shock?

Resource links provided by NLM:


Further study details as provided by Herlev Hospital:

Enrollment: 130
Study Start Date: November 2005
Study Completion Date: April 2009
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Adult patients with early septic shock (< 24 h).
Criteria

Inclusion Criteria:

  • Fluid resuscitated septic shock < 24 h.

Exclusion Criteria:

  • Septic shock > 24 h.
  • Pathology in the rectum.
  • Bleeding per rectum.
  • Limitation of therapy.
  • Where informed consent from relatives cannot be obtained.
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00197938


Locations
Denmark
Dept. of Intensive Care 4131, Rigshospitalet
Copenhagen, Denmark, DK-2100
Dept. of Intensive Care, Glostrup University Hospital
Glostrup, Denmark, DK-2600
Dept. of Intensive Care, Gentofte University Hospital
Hellerup, Denmark, DK-2900
Dept. of Intensive Care, Herlev University Hospital
Herlev, Denmark, DK-2730
Finland
Dept. of Intensive Care, Tampere University Hospital
Tampere, Finland, 33521
Sponsors and Collaborators
Herlev Hospital
Investigators
Study Chair: Anders Perner, MD, PhD Dept. of Anaesthesia and Intensive Care, Herlev University Hospital, DK-2730 Herlev
  More Information

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
ClinicalTrials.gov Identifier: NCT00197938     History of Changes
Other Study ID Numbers: KA 05091m
First Submitted: September 14, 2005
First Posted: September 20, 2005
Last Update Posted: June 9, 2009
Last Verified: June 2009

Additional relevant MeSH terms:
Shock, Septic
Sepsis
Infection
Systemic Inflammatory Response Syndrome
Inflammation
Pathologic Processes
Shock