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Low-Dose Endotoxemia and the Acute Phase Response

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ClinicalTrials.gov Identifier: NCT00197899
Recruitment Status : Unknown
Verified September 2005 by Herlev Hospital.
Recruitment status was:  Active, not recruiting
First Posted : September 20, 2005
Last Update Posted : December 13, 2005
Sponsor:
Information provided by:

Study Description
Brief Summary:
The purpuse of this study is to examine the acute phase respons when different doses of E. Coli Endotoxin is injected in healty volunters.

Condition or disease Intervention/treatment
Endotoxemia Sepsis Drug: E. Coli endotoxin

Study Design

Study Type : Interventional  (Clinical Trial)
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double
Primary Purpose: Diagnostic
Study Start Date : March 2004
Estimated Study Completion Date : January 2005
Arms and Interventions


Outcome Measures

Eligibility Criteria

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 40 Years   (Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria: Healty volunteers -

Exclusion Criteria:

Infection 14 days prior to the trial Regular medication Present and /or former heart disease -

Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00197899


Locations
Denmark
Department of Intensive Care
Copenhagen, Copenhagen County, Denmark, 2730
Sponsors and Collaborators
Herlev Hospital
Investigators
Study Chair: Bente K Pedersen, MD, DMSc Department of Infectious Diseases 7641, University Hospital of Copenhagen, H:S Rigshospitalet
Principal Investigator: Dorthe H Olsen, MD Department of Intensive Care, Herlev University Hospital
Study Director: Dorthe H Olsen, DM Department of Intensive Care, Herlev University Hospital
More Information

ClinicalTrials.gov Identifier: NCT00197899     History of Changes
Other Study ID Numbers: KA 04015
First Posted: September 20, 2005    Key Record Dates
Last Update Posted: December 13, 2005
Last Verified: September 2005

Additional relevant MeSH terms:
Endotoxemia
Bacteremia
Sepsis
Infection
Toxemia
Systemic Inflammatory Response Syndrome
Inflammation
Pathologic Processes