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Low-Dose Endotoxemia and the Acute Phase Response

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified September 2005 by Herlev Hospital.
Recruitment status was:  Active, not recruiting
Information provided by:
Herlev Hospital Identifier:
First received: September 13, 2005
Last updated: December 12, 2005
Last verified: September 2005
The purpuse of this study is to examine the acute phase respons when different doses of E. Coli Endotoxin is injected in healty volunters.

Condition Intervention
Endotoxemia Sepsis Drug: E. Coli endotoxin

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double
Primary Purpose: Diagnostic

Further study details as provided by Herlev Hospital:

Study Start Date: March 2004
Estimated Study Completion Date: January 2005

Ages Eligible for Study:   18 Years to 40 Years   (Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   No

Inclusion Criteria: Healty volunteers -

Exclusion Criteria:

Infection 14 days prior to the trial Regular medication Present and /or former heart disease -

  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00197899

Department of Intensive Care
Copenhagen, Copenhagen County, Denmark, 2730
Sponsors and Collaborators
Herlev Hospital
Study Chair: Bente K Pedersen, MD, DMSc Department of Infectious Diseases 7641, University Hospital of Copenhagen, H:S Rigshospitalet
Principal Investigator: Dorthe H Olsen, MD Department of Intensive Care, Herlev University Hospital
Study Director: Dorthe H Olsen, DM Department of Intensive Care, Herlev University Hospital
  More Information Identifier: NCT00197899     History of Changes
Other Study ID Numbers: KA 04015
Study First Received: September 13, 2005
Last Updated: December 12, 2005

Additional relevant MeSH terms:
Systemic Inflammatory Response Syndrome
Pathologic Processes processed this record on August 22, 2017