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Cytokine Gene Polymorphisms in Gastric Diseases

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ClinicalTrials.gov Identifier: NCT00197470
Recruitment Status : Unknown
Verified September 2005 by Hamamatsu University.
Recruitment status was:  Recruiting
First Posted : September 20, 2005
Last Update Posted : September 20, 2005
Sponsor:
Collaborator:
Yokoyama Foundation for Clinical Pharmacology
Information provided by:
Hamamatsu University

Study Description
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Brief Summary:
Recently, cytokine polymorphisms are considered to play an important role in the pathogenesis of peptic ulcer and gastric cancer. We intended to clarify the association between polymorphisms of pro-inflammatory and anti-inflammatory cytokines, and the susceptibility to gastric cancer, gastric ulcer and duodenal ulcer in Japan, and to detect the individuals who have higher risks for gastrointestinal disease development.

Condition or disease Intervention/treatment Phase
Gastric Ulcer Duodenal Ulcer Gastric Cancer Procedure: IL-1, TNF-alpha, Il-10 Not Applicable

Detailed Description:

H. pylori infection has close associations with the development of peptic ulcer diseases as well as gastric cancer, gastric adenoma, and gastric MALT lymphoma. The association of the host genetics with the susceptibility to various gastroduodenal disorders has been intensively investigated in the pathogenesis of peptic ulcer and gastric cancer by H. pylori infection .

In chronic active gastritis induced by H. pylori infection, activated neutrophils and mononuclear cells produce several pro-inflammatory and anti-inflammatory cytokines. In fact, levels of pro-inflammatory and anti-inflammatory cytokines are elevated in gastric mucosa infected with H. pylori.

Cytokine polymorphisms are associated with various inflammatory and autoimmune diseases. Recently, cytokine polymorphisms are considered to play an important role in the pathogenesis of peptic ulcer and gastric cancer. However, the roles of the IL-10 polymorphisms on the pathogenesis of H. pylori-related gastric cancer and peptic ulcer have not been fully elucidated.It is unclear whether pro-inflammatory and anti-inflammatory cytokines polymorphisms were associated with pathogenesis of peptic ulcer and gastric cancer in Japan. Then, we intended to clarify the association between polymorphisms of IL-10 and the susceptibility to gastric cancer, gastric ulcer and duodenal ulcer in Japan, and to detect the individuals who have higher risks for gastrointestinal disease development.


Study Design
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Study Type : Interventional  (Clinical Trial)
Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Diagnostic
Official Title: Effects of Pro-Inflammatory and Anti-Inflammatory Cytokine Gene Polymorphism on the Development of Gastric Cancer and Peptic Ulcer in Japanese
Study Start Date : January 2000

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Arms and Interventions
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Outcome Measures
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Eligibility Criteria
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Ages Eligible for Study:   Child, Adult, Older Adult
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

Exclusion Criteria:

  • patinets without H. pylori
Contacts and Locations
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To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00197470


Contacts
Contact: Mitsushige Sugimoto +81-53-435-2261 mitsu@hama-med.ac.jp

Locations
Japan
Hamamatsu University School of Medicine Recruiting
Hamamatsu, Japan, 431-3192
Contact: Mitsushige Sugimoto    +81-53-435-2261    mitsu@hama-med.ac.jp   
Sponsors and Collaborators
Hamamatsu University
Yokoyama Foundation for Clinical Pharmacology
Investigators
Study Chair: MItsushige Sugimoto First department of medicine, Hamamatsu University School of medicine
More Information
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ClinicalTrials.gov Identifier: NCT00197470     History of Changes
Other Study ID Numbers: Mitsu-001
First Posted: September 20, 2005    Key Record Dates
Last Update Posted: September 20, 2005
Last Verified: September 2005

Additional relevant MeSH terms:
Ulcer
Stomach Neoplasms
Stomach Ulcer
Duodenal Ulcer
Pathologic Processes
Gastrointestinal Neoplasms
Digestive System Neoplasms
Neoplasms by Site
 Neoplasms
Digestive System Diseases
Gastrointestinal Diseases
Stomach Diseases
Peptic Ulcer
Duodenal Diseases
Intestinal Diseases