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Prospective Randomized Evaluation of Antibiotic Regimen Following Appendectomy for Perforated Appendicitis

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ClinicalTrials.gov Identifier: NCT00195923
Recruitment Status : Completed
First Posted : September 20, 2005
Last Update Posted : April 6, 2007
Sponsor:
Information provided by:
Children's Mercy Hospital Kansas City

Brief Summary:
The purpose of this study is to compare traditional triple antibiotic therapy against dual single day dosing antibiotic therapy in the management of perforated appendicitis in children.

Condition or disease Intervention/treatment
Perforated Appendicitis Drug: Ampicillin, gentamicin, clindamycin, flagyl, ceftazidime

  Show Detailed Description

Study Type : Observational
Enrollment : 100 participants
Observational Model: Defined Population
Observational Model: Natural History
Time Perspective: Cross-Sectional
Time Perspective: Prospective
Official Title: Prospective Randomized Evaluation of Antibiotic Regimen Following Appendectomy for Perforated Appendicitis
Study Start Date : April 2005
Actual Study Completion Date : January 2007

Resource links provided by the National Library of Medicine

Drug Information available for: Ampicillin





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Ages Eligible for Study:   1 Month to 18 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • All patients under 18 years of age found to have perforated appendicitis at the time of operation for appendicitis and whose parents give informed permission will be included in the study.

Exclusion Criteria:

  • Patients with a normal or non-perforated appendix at the time of appendectomy, those without parental permission, or those with a documented allergy to any of the antibiotics used in either regimen will be excluded from the study. Patients 18 years or older will not be included in the study

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00195923


Locations
United States, Missouri
The Children’s Mercy Hospital
Kansas CIty, Missouri, United States, 64108
Sponsors and Collaborators
Children's Mercy Hospital Kansas City
Investigators
Principal Investigator: Daniel J Ostlie, MD Children's Mercy Hospital Kansas City

ClinicalTrials.gov Identifier: NCT00195923     History of Changes
Other Study ID Numbers: 04-12-149
First Posted: September 20, 2005    Key Record Dates
Last Update Posted: April 6, 2007
Last Verified: September 2005

Keywords provided by Children's Mercy Hospital Kansas City:
appendicitis
perforation

Additional relevant MeSH terms:
Appendicitis
Intraabdominal Infections
Infection
Gastroenteritis
Gastrointestinal Diseases
Digestive System Diseases
Cecal Diseases
Intestinal Diseases
Anti-Bacterial Agents
Clindamycin
Gentamicins
Ceftazidime
Ampicillin
Anti-Infective Agents
Protein Synthesis Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action