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The Serotonergic Transmitter System in Dementia and Affective Disorders

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ClinicalTrials.gov Identifier: NCT00192998
Recruitment Status : Unknown
Verified September 2005 by Rigshospitalet, Denmark.
Recruitment status was:  Recruiting
First Posted : September 19, 2005
Last Update Posted : September 27, 2007
Information provided by:

Study Description
Brief Summary:
The aim of this project is to examine the serotonergic transmitter system using functional imaging of the brain (positron emission tomography [PET]) to gain knowledge about early pathophysiological changes in Alzheimer's dementia and mood disorders.

Condition or disease
Mood Disorders Alzheimer Disease

Study Design

Study Type : Observational
Estimated Enrollment : 100 participants
Observational Model: Defined Population
Observational Model: Natural History
Time Perspective: Cross-Sectional
Time Perspective: Prospective
Study Start Date : October 2003

Groups and Cohorts

Outcome Measures

Eligibility Criteria

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Moderate to severe Alzheimer's disease
  • Individuals genetically predisposed to affective disorder
  • Healthy gender and age matched controls

Exclusion Criteria:

  • Contraindications to magnetic resonance imaging (MRI)
  • Use of psychoactive drugs
  • Past or present affective disorder
  • Other systemic diseases that may affect brain function
Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00192998

Contact: Vibe G. Frokjaer, MD +45 3545 6714 vibe@nru.dk
Contact: Steen G. Hasselbalch, MD sgh@nru.dk

Neurobiological Research Unit Recruiting
Copenhagen, Denmark, 2100
Contact: Vibe G. Frokjaer, MD    +45 3545 6714    vibe@nru.dk   
Principal Investigator: Vibe G. Frokjaer, MD         
Sponsors and Collaborators
Rigshospitalet, Denmark
Principal Investigator: Vibe G. Frokjaer, MD Neurobiological Research Unit, Copenhagen University Hospital, Denmark
More Information

Additional Information:
ClinicalTrials.gov Identifier: NCT00192998     History of Changes
Other Study ID Numbers: SERT-AD
First Posted: September 19, 2005    Key Record Dates
Last Update Posted: September 27, 2007
Last Verified: September 2005

Keywords provided by Rigshospitalet, Denmark:
Affective disorder
Alzheimer dementia
healthy controls

Additional relevant MeSH terms:
Alzheimer Disease
Mood Disorders
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Neurodegenerative Diseases
Neurocognitive Disorders
Mental Disorders