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The Serotonergic Transmitter System in Dementia and Affective Disorders

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified September 2005 by Rigshospitalet, Denmark.
Recruitment status was:  Recruiting
Information provided by:
Rigshospitalet, Denmark Identifier:
First received: September 13, 2005
Last updated: September 26, 2007
Last verified: September 2005
The aim of this project is to examine the serotonergic transmitter system using functional imaging of the brain (positron emission tomography [PET]) to gain knowledge about early pathophysiological changes in Alzheimer's dementia and mood disorders.

Mood Disorders Alzheimer Disease

Study Type: Observational
Study Design: Observational Model: Defined Population
Observational Model: Natural History
Time Perspective: Cross-Sectional
Time Perspective: Prospective

Resource links provided by NLM:

Further study details as provided by Rigshospitalet, Denmark:

Estimated Enrollment: 100
Study Start Date: October 2003

Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Moderate to severe Alzheimer's disease
  • Individuals genetically predisposed to affective disorder
  • Healthy gender and age matched controls

Exclusion Criteria:

  • Contraindications to magnetic resonance imaging (MRI)
  • Use of psychoactive drugs
  • Past or present affective disorder
  • Other systemic diseases that may affect brain function
  Contacts and Locations
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Please refer to this study by its identifier: NCT00192998

Contact: Vibe G. Frokjaer, MD +45 3545 6714
Contact: Steen G. Hasselbalch, MD

Neurobiological Research Unit Recruiting
Copenhagen, Denmark, 2100
Contact: Vibe G. Frokjaer, MD    +45 3545 6714   
Principal Investigator: Vibe G. Frokjaer, MD         
Sponsors and Collaborators
Rigshospitalet, Denmark
Principal Investigator: Vibe G. Frokjaer, MD Neurobiological Research Unit, Copenhagen University Hospital, Denmark
  More Information

Additional Information: Identifier: NCT00192998     History of Changes
Other Study ID Numbers: SERT-AD
Study First Received: September 13, 2005
Last Updated: September 26, 2007

Keywords provided by Rigshospitalet, Denmark:
Affective disorder
Alzheimer dementia
healthy controls

Additional relevant MeSH terms:
Alzheimer Disease
Mood Disorders
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Neurodegenerative Diseases
Neurocognitive Disorders
Mental Disorders processed this record on September 20, 2017