The CRT-KIR Study (Cardiac Resynchronization Therapy [CRT] in the Early Phase After Heart Surgery)
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|ClinicalTrials.gov Identifier: NCT00192946|
Recruitment Status : Withdrawn (The study population is smaller than expected. No subjects were included.)
First Posted : September 19, 2005
Last Update Posted : July 10, 2007
In patients with broad QRS complexes on electrocardiogram (ECG), the delayed electrical activation of the left heart chamber will cause abnormal contraction.This has been shown to be possible to treat by a special pacemaker treatment which includes pacing of the left heart chamber (= CRT treatment).
In this study the researchers will investigate the effect of acute CRT treatment in the early phase after open heart surgery.
|Condition or disease||Intervention/treatment||Phase|
|Bundle-Branch Block||Procedure: Temporary cardiac resynchronization therapy||Not Applicable|
Patients with bundle branch block have a delayed electrical activation of the left ventricle causing abnormal contractility of the left ventricle.
We hypothesize that patients may benefit from short term (= 72 hours) CRT (Cardiac Resynchronization Therapy) in the early phase after open heart surgery.
Patients: reduced LV function and bundle branch block.
Study type: randomisation to CRT versus standard postoperative treatment
Study variables: cardiac output, echocardiographic measures, p-BNP and hours with inotropic therapy.
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||60 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||None (Open Label)|
|Official Title:||Cardiac Resynchronization Therapy (CRT) in the Early Phase After Heart Surgery|
|Estimated Study Completion Date :||September 2008|
- Non invasive cardiac output after 72 hours CRT (versus control) treatment
- Echocardiographic measures of left ventricular (LV) function
- Mixed venous oxygen saturation
- Invasively determined cardiac output
- Plasma brain natriuretic peptide (p-BNP)
- Number of hours with inotropic treatment
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00192946
|Principal Investigator:||Jesper H Svendsen, MD||Rigshospitalet, Denmark|