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Growth Hormone and Heart Failure

This study has been terminated.
Information provided by:
Assistance Publique - Hôpitaux de Paris Identifier:
First received: September 14, 2005
Last updated: NA
Last verified: April 2002
History: No changes posted
Heart failure induces modification in several neurohormonal systems. The aim of this study is to determine if the growth hormone/IGF1 axis is modified in heart failure patients compared to healthy volunteers.

Heart Failure, Congestive

Study Type: Observational
Study Design: Observational Model: Case Control
Observational Model: Natural History
Time Perspective: Cross-Sectional
Time Perspective: Retrospective/Prospective
Official Title: Modifications of the Growth Hormone/IGF1 Axis in Heart Failure Patients

Resource links provided by NLM:

Further study details as provided by Assistance Publique - Hôpitaux de Paris:

Estimated Enrollment: 180
Study Start Date: September 2000
Estimated Study Completion Date: February 2003
Detailed Description:
One hundred and sixty three heart failure patients were evaluated by clinical examination, echocardiography, exercise test and measurement of blood BNP. Growth hormone and IGF-1 plasma levels were determined in each patient. The same biological measurements were performed in a group of 148 healthy controls. Comparisons were performed between groups for Growth hormone plasma level, IGF-1 plasma level and Growth hormone/IGF-1 index. A correlation between the severity of heart failure and the different biological parameters was searched.

Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Heart failure patients in stable condition

Exclusion Criteria:

  • cancer
  • pituitary disease
  Contacts and Locations
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Please refer to this study by its identifier: NCT00190359

Sponsors and Collaborators
Assistance Publique - Hôpitaux de Paris
Principal Investigator: Patrick Maison, MD, PhD APHP
  More Information Identifier: NCT00190359     History of Changes
Other Study ID Numbers: CRC00007
Study First Received: September 14, 2005
Last Updated: September 14, 2005

Keywords provided by Assistance Publique - Hôpitaux de Paris:
heart failure
growth substances

Additional relevant MeSH terms:
Heart Failure
Heart Diseases
Cardiovascular Diseases
Hormones, Hormone Substitutes, and Hormone Antagonists
Physiological Effects of Drugs processed this record on August 17, 2017