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Effect of Bi-ventricular Pacing on Autonomous Nervous System

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified December 2004 by Far Eastern Memorial Hospital.
Recruitment status was:  Not yet recruiting
Information provided by:
Far Eastern Memorial Hospital Identifier:
First received: September 12, 2005
Last updated: October 5, 2010
Last verified: December 2004
Patients with congestive heart failure are often associated with delayed intraventricular depolarization which causing dyssynchrony and an inefficient pattern of left ventricular contraction. A number of studies have shown that bi-ventricular or left ventricular pacing improves indexes of systolic function as well as decreases sympathetic activation in patients with severe left ventricular systolic dysfunction, dilated cardiomyopathy and a major left-sided intraventricular conduction disorder such as left bundle branch block. One recent study also demonstrated that bi-ventricular pacing can shift heart rate variability (HRV) toward a more favorable profile. Baroreflex sensitivity (BRS) is a measure of the negative feedback properties that interact in modulating the dynamic heart rate and arterial pressure fluctuations. Blunted BRS is found to be associated with an increased risk for both cardiac deaths and arrhythmic events. However, the effect of bi-ventricular pacing on BRS has never been studied. In the present proposal, we plan to measure common hemodynamic parameters, BRS and HRV in a group of heart failure patients receiving open heart surgery in different pacing conditions (bi-ventricular pacing, single LV pacing, single RV pacing). The major aims are to investigate the effect of bi-ventricular pacing on BRS and to clarify the underlying mechanisms.

Condition Intervention
Congestive Heart Failure Device: Bi-ventricular pacing

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: Effect of Bi-ventricular Pacing on Autonomous Nervous System

Resource links provided by NLM:

Further study details as provided by Far Eastern Memorial Hospital:


Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Patients with normal sinus rhythm proposed to undergo coronary artery bypass surgery.

Exclusion Criteria:

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Please refer to this study by its identifier: NCT00190138

Sponsors and Collaborators
Far Eastern Memorial Hospital
Study Chair: Kuan-Ming Chiu, M.D. Far Eastern Memorial Hospital
  More Information Identifier: NCT00190138     History of Changes
Other Study ID Numbers: FEMH-93014
Study First Received: September 12, 2005
Last Updated: October 5, 2010

Keywords provided by Far Eastern Memorial Hospital:
Bi-ventricular pacing
ventricular resynchronization
baroreflex sensitivity
heart rate variability

Additional relevant MeSH terms:
Heart Failure
Heart Diseases
Cardiovascular Diseases processed this record on September 18, 2017