Clozapine IM and Aggression in Schizophrenic Patients

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00189995
Recruitment Status : Withdrawn
First Posted : September 19, 2005
Last Update Posted : July 24, 2013
Information provided by (Responsible Party):
Vladimir Lerner, Beersheva Mental Health Center

Brief Summary:

Aggressive, persistent aggression and impulsive behavior are frequently observed in schizophrenic patients. According to some researchers "more than 50% of all psychiatric patients and 10% of schizophrenic patients show aggressive symptoms varying from threatening behavior and agitation to assault"(1). It is a common cause of psychiatric admission and is a therapeutic issue. The treatment of these symptoms is a clinical problem for both patients and staff. Violent behavior, a major detrimental factor in stigmatization of the mentally ill, also poses physical danger for the patients themselves. Current pharmacotherapy of pathologic aggression involves the use of multiple agents (typical and atypical antipsychotics, benzodiazepines, mood stabilizers, beta-blockers, antiandrogenic hormones, and selective serotonin reuptake inhibitors) on empiric basis, with varying degrees of response (2-6). Unfortunately, these approaches lead to numerous side effects. Poor or noncompliance with pharmacotherapy makes it difficult to choose the appropriate preparation. Currently, typical neuroleptics are still the first choice in treating acute aggressive symptoms, while risperidone and olanzapine could be alternatives (5-7). Typical depot neuroleptics should be considered in cases where medication compliance is a problem. Most clinical information on treating of aggression has been collected about atypical neuroleptics, particularly regarding clozapine.

Clozapine is indicated in psychotic state and/or in drug-resistant schizophrenic patients. According to the FDA - it is the drug of choice in suicidal and aggressive patients, due-to psychotic state. It was found helpful in nearly 30% of resistant schizophrenic patients. Concerning the parenteral administration of clozapine - very little data is available today.

This study aims to investigate efficacy and safety (psychopathology, and side effects) of parenteral clozapine in treatment of aggressive behavior in schizophrenic patients in a double-blind trial.

Condition or disease Intervention/treatment Phase
Schizophrenia Drug: clozapine Drug: haloperidol Phase 3

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 0 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double
Primary Purpose: Treatment
Official Title: Intramuscular Clozapine in the Management of Aggression in Schizophrenic Patients

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Schizophrenia

Primary Outcome Measures :
  1. Positive and Negative Syndrome Scale
  2. Overt Aggression Scale

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 65 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • schizophrenic, schizoaffective, or schizophreniform according to DSM-IV
  • treatment-resistant
  • presenting pathologic violent-aggressive behavior on admission
  • at risk for self damage
  • age: 18-65
  • patient is not participating in any other study at time of this study
  • minimal score of 70 on PANSS
  • prior resistance to at least 2 different classes of neuroleptics
  • OAS scores of at least 4 points in physical aggression sections and at least 2 points in verbal aggression section

Exclusion Criteria:

  • neutropenia or any other abnormal CBC result
  • myeloproliferative disease
  • chronic physical diseases such as liver, renal or cardiac diseases
  • history of alcohol or drug abuse
  • history of drug induced granulocytopenia/agranulocytosis
  • alcoholic/drug psychosis or intoxication
  • carbamazepine or other bone marrow suppressor treatment
  • uncontrolled epilepsy
  • paralytic ileus
  • hypersensitivity to clozapine

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00189995

Beersheva Mental Health Center
Beersheva, Israel
Nes Ziona Medical Center
Nes Ziona, Israel
Sponsors and Collaborators
Beersheva Mental Health Center
Principal Investigator: Valdimir Lerner, MD, PhD Ben-Gurion University of the Negev
Principal Investigator: Baruch Spivak, MD Tel Aviv University
Principal Investigator: Chanoch Midownik, MD Ben-Gurion University of the Negev

Responsible Party: Vladimir Lerner, Associated Professor, Beersheva Mental Health Center Identifier: NCT00189995     History of Changes
Other Study ID Numbers: BMHC-4000
First Posted: September 19, 2005    Key Record Dates
Last Update Posted: July 24, 2013
Last Verified: October 2005

Keywords provided by Vladimir Lerner, Beersheva Mental Health Center:

Additional relevant MeSH terms:
Schizophrenia Spectrum and Other Psychotic Disorders
Mental Disorders
Behavioral Symptoms
Autonomic Agents
Peripheral Nervous System Agents
Physiological Effects of Drugs
Gastrointestinal Agents
Antipsychotic Agents
Tranquilizing Agents
Central Nervous System Depressants
Psychotropic Drugs
Dopamine Antagonists
Dopamine Agents
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action
Anti-Dyskinesia Agents
Serotonin Antagonists
Serotonin Agents
GABA Antagonists
GABA Agents