Azathioprine Versus Corticosteroids in Parthenium Dermatitis
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT00189397|
Recruitment Status : Completed
First Posted : September 19, 2005
Last Update Posted : May 8, 2008
The dermatitis caused by the substances which come in contact with the skin is known as contact dermatitis. When such a reaction is caused by the agents suspended in the air, it is called air-borne contact dermatitis (ABCD). Parthenium hysterophorus at present is the commonest cause of ABCD in India though in some cases other plants have also been found to cause ABCD. Parthenium dermatitis is one of the major health problems in dermatology in our country. Though it has very little mortality, the disease normally continues to persist with variable remissions and relapses causing great distress and morbidity. Corticosteroids, topical and systemic have been the mainstay of the treatment so far. Therefore, the patients with ABCD who have to take corticosteroids for long periods of time tend to develop severe and sometimes irreversible side effects of the therapy. Azathioprine is an immunosuppressive drug which acts by inhibiting the T lymphocytes. In our previous studies we have been able to induce remissions in these patients with azathioprine used as daily as well as monthly bolus dose, without having to use systemic corticosteroids. The side effect with azathioprine in these studies were almost absent.
We have therefore planned to study the therapeutic efficacy of azathioprine weekly pulse doses versus daily azathioprine in achieving remissions in patients having Parthenium dermatitis and to monitor the side effects of both the regimens.
|Condition or disease||Intervention/treatment||Phase|
|Parthenium Dermatitis||Drug: azathioprine and corticosteroids for Parthenium dermatitis||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Intervention Model:||Parallel Assignment|
|Official Title:||Azathioprine Versus Corticosteroids for the Treatment of Parthenium Dermatitis|
|Study Start Date :||February 2003|
|Actual Primary Completion Date :||October 2005|
|Actual Study Completion Date :||January 2006|
- Clinical remission and side effects
- Duration of remission
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00189397
|Department of Dermatology, AIIMS|
|New Delhi, Delhi, India, 110029|
|Principal Investigator:||Kaushal K Verma, MD||All India Institute of Medical Sciences, New Delhi|