Trial record 11 of 89 for:    Open Studies | "Mesothelioma"

Early Diagnosis of Lung Cancer and Mesothelioma in Prior Asbestos Workers

This study is currently recruiting participants. (see Contacts and Locations)
Verified May 2015 by University Health Network, Toronto
Information provided by (Responsible Party):
University Health Network, Toronto Identifier:
First received: September 12, 2005
Last updated: May 27, 2015
Last verified: May 2015

Occupational exposure to asbestos is known increase the risk of developing cancer of the lungs (bronchogenic carcinoma) or of the pleura (mesothelioma). Symptoms are subtle and non-specific, diagnosis is often late and the prognosis consequently is dismal. Currently there is no accepted non-invasive tool for the early diagnosis of mesothelioma or lung cancer in asbestos-exposed subjects. In the last decade, low-dose computed tomography (LDCT) has been successfully developed and validated for the early diagnosis of lung cancer in high-risk smokers. Malignant mesothelioma might, in an early stage, resemble a benign pleural plaque, which is a common finding after asbestos exposure. We target to develop low-dose CT as a tool to serially image the pleural plaques, quantify their individual and overall volume, compute the growth rate with time, and, as such, identify the presence of mesothelioma early, before symptoms occur.

Lung Cancer

Study Type: Observational
Study Design: Observational Model: Case Control
Official Title: Early Diagnosis of Mesothelioma and Lung Cancer Following Asbestos Exposure Using Low-dose Computed Tomography

Resource links provided by NLM:

Further study details as provided by University Health Network, Toronto:

Estimated Enrollment: 2000
Study Start Date: March 2005
Estimated Study Completion Date: March 2017
Estimated Primary Completion Date: March 2017 (Final data collection date for primary outcome measure)
prior occupational exposure to asbestos and / or documented pleural plaques on a chest x-ray


Ages Eligible for Study:   30 Years to 85 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

prior exposure to asbestos and or documented pleural plaques


Inclusion Criteria:

prior asbestos exposure at least 20 years ago and/or documented pleural plaques (chest x-ray evidence)

Resident of Ontario, Canada

Exclusion Criteria:

prior cancer (except non-melanotic skin cancer)

  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00188890

Contact: Demetris Patsios, MD Tel: (416) 603-5800 ext 2583
Contact: Brenda O'Sullivan 416-340-4800 ext 5686 Brenda.O'

Canada, Ontario
Princess Margaret Hospital Recruiting
Toronto, Ontario, Canada
Contact: Demetris Patsios, MD    Tel: (416) 603-5800 ext 2583   
Contact: Brenda O'Sullivan, MD    416-340-4800 ext 5686    brenda.o'   
Sponsors and Collaborators
University Health Network, Toronto
Principal Investigator: Demetris Patsios, MD University Health Network, Toronto
Principal Investigator: Marc de Perrot, MD University Health Network, Toronto
  More Information

No publications provided

Responsible Party: University Health Network, Toronto Identifier: NCT00188890     History of Changes
Other Study ID Numbers: Asbestos Screening Study
Study First Received: September 12, 2005
Last Updated: May 27, 2015
Health Authority: Canada: Health Canada

Keywords provided by University Health Network, Toronto:
Lung Cancer
Early Diagnosis

Additional relevant MeSH terms:
Lung Neoplasms
Lung Diseases
Neoplasms by Histologic Type
Neoplasms by Site
Neoplasms, Glandular and Epithelial
Neoplasms, Mesothelial
Respiratory Tract Diseases
Respiratory Tract Neoplasms
Thoracic Neoplasms processed this record on September 01, 2015