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Postoperative Pain After Medical Abortion Under Local Anesthesia : Comparison of Several Analgesic Regimen

This study has been completed.
Information provided by:
University Hospital, Angers Identifier:
First received: September 12, 2005
Last updated: December 28, 2005
Last verified: September 2005
  • To compare postoperative analgesia by paracetamol 1gr or ketoprofen 100 mg or the combination of these two analgesics
  • each treatment beeing allocated by randomization

Condition Intervention
Abortion, Induced Drug: paracetamol Drug: ketoprofen Drug: ketoprofen + paracetamol

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single
Primary Purpose: Treatment
Official Title: Postoperative Pain After Medical Abortion Under Local Anesthesia : a Prospective and Randomized Trial Comparing Several Analgesic Regimen

Resource links provided by NLM:

Further study details as provided by University Hospital, Angers:

Primary Outcome Measures:
  • postoperative pain rating

Secondary Outcome Measures:
  • morphine consumption
  • patient satisfaction

Estimated Enrollment: 240
Study Start Date: September 2002
Estimated Study Completion Date: August 2003
Detailed Description:
  • 240 pregnant women who undewent a medical abortion by aspiration, under local anesthesia, (day case surgery) were enrolled after informed consent and signed approval
  • according to randomization, they received one hour before medical abortion procedure performed under local anesthesia of the cervix, one of these three diffrente analgesics :

    • paracetamol 1 gr
    • ketoprofen 100 mg
    • the association of both Postprocedure pain was recorded, by nurse, using a visual analog scale (VAS), 7 times before and after the procedure, until the discharge of the patient.
  • if VAS was above 40 on two consecutive measurements a morphine injection was given.
  • the number and total amount of morphine was recorded.
  • satisfaction was recorded within the 3 postoperative day by a telephone inquiry.

Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • pregnant women
  • medical abortion performed in day case surgery under local anesthesia
  • informed written consent

Exclusion Criteria:

  • under 18 year old
  Contacts and Locations
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Please refer to this study by its identifier: NCT00188071

Dept of Anesthesia - CHU
Angers, France, 49933
Sponsors and Collaborators
University Hospital, Angers
Study Chair: Jean Claude Granry, MD University hospital Angers - France
Principal Investigator: Emmanuel Mucci, MD University hospital Angers - France
Study Director: Christine Monrigal, MD Dept of Anesthesia, CHU, Angers - France
  More Information Identifier: NCT00188071     History of Changes
Other Study ID Numbers: CP 02-02
Study First Received: September 12, 2005
Last Updated: December 28, 2005

Keywords provided by University Hospital, Angers:
medical abortion

Additional relevant MeSH terms:
Pain, Postoperative
Neurologic Manifestations
Nervous System Diseases
Postoperative Complications
Pathologic Processes
Signs and Symptoms
Sensory System Agents
Peripheral Nervous System Agents
Physiological Effects of Drugs
Analgesics, Non-Narcotic
Anti-Inflammatory Agents, Non-Steroidal
Anti-Inflammatory Agents
Antirheumatic Agents
Cyclooxygenase Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action processed this record on August 18, 2017