Growth Hormone Treatment of Young Growth Hormone-Deficient Adults
|ClinicalTrials.gov Identifier: NCT00187993|
Recruitment Status : Unknown
Verified September 2005 by University Hospital, Angers.
Recruitment status was: Recruiting
First Posted : September 16, 2005
Last Update Posted : September 16, 2005
Hypopituitary adults with all the hormonal deficiencies are well subsituted excepted for the growth hormone (GH) and died earlier than the rest of the population. GH deficiency involves a fat mass increase with regard to lean mass, an atherogenic lipidic profile and participating to osteopenia mechanism and decrease the life quality. All these dysfunctions are partially or totally corrected by the GH prescription with patient deficient since adulthood.
However, for patients deficient since childhood, no study have demonstrated that GH treatment during childhood present these same benefit when they are treated during adulthood.
Primary objective of this study is to examine that fat mass significantly decrease due to GH treatment in adulthood for patient GH deficient since childhood, treated by GH during childhood but stopped since the end of adolescence.
We compare the body composition and others energetic metabolism parameters in two patient groups, one treated by GH during 18 months, and the other with no treatment. Body composition and bone density are measured by pletysmography (DEXA). Metabolic parameters are : energetic balance (energy intake evaluation by questionnaire, energetic expenditure evaluated by doubly labelled water) and biologic parameters (lipidic profile, thyroid hormones).
This study will evaluate if the GH treatment of young GH deficient adults since childhood can be a benefit for body composition, lipidic profile and bone density.
|Condition or disease||Intervention/treatment|
|Growth Hormone Deficiency||Drug: Growth hormone|
|Study Type :||Observational|
|Estimated Enrollment :||30 participants|
|Observational Model:||Defined Population|
|Observational Model:||Natural History|
|Official Title:||Growth Hormone Treatment of Young Adults Deficient in Growth Hormone Since Childhood : Study of Body Composition Modifications.|
|Study Start Date :||May 2005|
|Estimated Study Completion Date :||August 2005|
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00187993
|UH of Angers||Recruiting|
|Angers, France, 49000|
|Contact: Rohmer Vincent, Professor email@example.com|
|Principal Investigator: Rohmer Vincent, Professor|
|UH of Brest||Not yet recruiting|
|Contact: Sonnet Emmanuel, Dr firstname.lastname@example.org|
|Principal Investigator: Sonnet Emmanuel, Doctor|
|UH of Caen||Not yet recruiting|
|Contact: Reznik email@example.com|
|Principal Investigator: Reznik Yves, Professor|
|UH of Limoges||Not yet recruiting|
|Contact: Tessier Marie-Pierre, Professor firstname.lastname@example.org|
|Principal Investigator: Tessier Marie-Pierre, Professor|
|UH of Rennes||Not yet recruiting|
|Rennes, France, 35000|
|Contact: Lorcy email@example.com|
|UH of Tours||Not yet recruiting|
|Contact: Lecomte firstname.lastname@example.org|
|Principal Investigator: Lecompte Pierre, Professor|
|Study Director:||Rohmer Vincent, Professor||CHU of Angers|