WISE ARIC: Retinal Photography in Women With Chest Pain
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT00187954|
Recruitment Status : Completed
First Posted : September 16, 2005
Last Update Posted : October 5, 2015
The purposes of this study are:
- To correlate the severity of retinal arteriolar narrowing and other microvascular changes, as determined from retinal photographs and video imaging, to measures of coronary microvascular function in women evaluated for chest pain.
- To evaluate measures of vascular compliance with applanation tonometry and photoplethysmography using a nasal alar probe.
|Condition or disease||Phase|
|Chest Pain||Phase 4|
Women who meet study eligibility criteria and provide written informed consent will have a baseline physical exam, including measurements of heart rate, blood pressure, weight. Medical history will be updated, specifically cardiovascular events (hospitalizations, procedures) since last contact and current medications. Patients will be scheduled for retinal photography. Those who are currently being screened and qualify for EWISE or other ancillary studies will have retinal photography scheduled as close to the index CFR as possible and prior to receiving randomized therapy.
The retinal photography will follow a standardized written protocol.
For the second protocol, 100 patients will be scheduled for an appointment in the Eye clinic where they will meet the Women's Ischemic Syndrome Evaluation (WISE)/Atherosclerosis Risk in Communities (ARIC) staff and complete the baseline information and have a brief physical examination. They will then have provocative testing completed with retinal imaging.
|Study Type :||Observational|
|Actual Enrollment :||160 participants|
|Official Title:||Retinal Photography in Women With Chest Pain: A WISE/ARIC Collaboration|
|Study Start Date :||June 2003|
|Primary Completion Date :||September 2014|
|Study Completion Date :||September 2014|
- Arteriole to venule ratio (AVR) [ Time Frame: baseline ]retinal arteriolar and venule diameters reflected as a ratio
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00187954
|United States, Florida|
|University of Florida|
|Gainesville, Florida, United States, 32610|
|Principal Investigator:||Eileen Handberg, PHD||University of Florida|