Regulation of Endocrine, Metabolic, Immune and Bioenergetic Responses in Sepsis
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|ClinicalTrials.gov Identifier: NCT00187824|
Recruitment Status : Unknown
Verified March 2004 by University College London Hospitals.
Recruitment status was: Recruiting
First Posted : September 16, 2005
Last Update Posted : September 16, 2005
|Condition or disease|
|Sepsis Critical Illness|
The objectives of this study are to examine the relationship between the severity of illness, and temporal changes in the activity of endocrine, metabolic and bioenergetic pathways, and consequent immune dysfunction in critically ill patients with sepsis and multiple organ failure in the Intensive Care Unit.
This study will be undertaken using sequential blood sampling (until ICU discharge) and muscle biopsies (to a maximum of 5) in critically ill patients (a) with or (b) without sepsis plus a comparator group undergoing elective orthopaedic surgery. A variety of hormonal, cytokine, immune and mitochondrial measures wil lbe then made to assess whether any relationship exists between alterations in these different pathways, and whether eventual survivors and non-survivors can be distinguished.
|Study Type :||Observational|
|Enrollment :||30 participants|
|Observational Model:||Defined Population|
|Observational Model:||Natural History|
|Official Title:||Regulation of Endocrine, Metabolic, Immune and Bioenergetic Responses in Sepsis|
|Study Start Date :||July 2004|
|Study Completion Date :||August 2007|
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00187824
|Contact: Mervyn Singer, MBBS MD FRCP||+44 207 679 email@example.com|
|UCL Hospitals NHS Foundation Trust||Recruiting|
|London, United Kingdom, NW1|
|Contact: Mervyn Singer, MD FRCP +44 207 679 9666 firstname.lastname@example.org|
|Sub-Investigator: Martin Stotz, MD|
|Sub-Investigator: Lucinda Barrett, MB MRCP|
|Sub-Investigator: Patrick Breen, MD|
|Study Director:||Mervyn Singer, MBBS MD FRCP||UCL/UCLH|
|Principal Investigator:||Geoff Bellingan, PhD FRCP||UCL/UCLH|
|Principal Investigator:||Paul Glynne, PhD FRCP||UCL/UCLH|