A 52 Week Open Label Trial of Memantine for Frontotemporal Lobar Degeneration
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This is a 52-week, multicenter, open label trial of memantine (Namenda) for frontotemporal lobar degeneration (FTLD). The goal is to determine the safety and tolerability of this FDA-approved medication for Alzheimer's Disease in patients with FTLD. Secondary outcome measures include cognitive batteries, rating scales for activities of daily living and neuropsychiatric symptoms. All patients receive the FDA-approved dose of this medication for Alzheimer's disease.
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Ages Eligible for Study:
40 Years to 80 Years (Adult, Senior)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Neary et al. Criteria for Frontotemporal Lobar Degeneration
Age 40 -80
CDR < 3 or MMSE > 15
Concurrent use of antipsychotic drugs or acetylcholinesterase inhibitors