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Transcranial Magnetic Treatment (TMS) in Unipolar Depression

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00186784
First Posted: September 16, 2005
Last Update Posted: August 3, 2011
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Collaborator:
Queen's University, Kingston, Ontario
Information provided by:
St. Joseph's Healthcare Hamilton
  Purpose

Repetitive Transcranial Magnetic Stimulation (rTMS) can improve mood and decrease sadness in patients with depression.

In this study, the investigators seek to increase their understanding about how rTMS improves depression, and to determine which form of rTMS is most effective for depression, when used in combination with antidepressant medication.


Condition Intervention Phase
Unipolar Depression Procedure: Transcranial Magnetic Stimulation (TMS) Early Phase 1

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: Double (Participant, Investigator)
Primary Purpose: Treatment
Official Title: Repetitive Transcranial Magnetic Stimulation (rTMS) in Unipolar Depression

Further study details as provided by St. Joseph's Healthcare Hamilton:

Primary Outcome Measures:
  • Hamilton Depression Rating Scale [ Time Frame: Pre TMS and post TMS ]
  • Beck Depression Rating Scale [ Time Frame: pre TMS and post TMS ]

Secondary Outcome Measures:
  • Quantitive Electroencephalographic(QEEG)activity and measures of regional cerebral blood flow [ Time Frame: pre TMS and post TMS as well as post phase II, second set of TMS ]

Enrollment: 21
Study Start Date: December 2000
Study Completion Date: July 2011
Primary Completion Date: July 2011 (Final data collection date for primary outcome measure)
Intervention Details:
    Procedure: Transcranial Magnetic Stimulation (TMS)
    treatment for 10 days
Detailed Description:
Patients will be assigned for 4 treatment arms, receiving either left high frequency plus right low frequency, or left high frequency plus right sham, or left sham, plus right low frequency, or left sham plus right sham treatment. All subjects will receive treatments for 10 days and will be followed for another 4 weeks.
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 65 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Major Depression
  • No physical health problems

Exclusion Criteria:

  • History of Epilepsy
  • Metal in the head/neck or skull
  • Pacemaker
  • Pregnancy
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00186784


Locations
Canada, Ontario
St.Joseph's Healthcare, rTMS Laboratory, Mood Disorders Program, 100 West Fifth Street
Hamilton, Ontario, Canada, L8N 3K7
Sponsors and Collaborators
St. Joseph's Healthcare Hamilton
Queen's University, Kingston, Ontario
Investigators
Principal Investigator: Gary Hasey, MD McMaster University
  More Information

Responsible Party: Dr. Gary M. Hasey, St. Joseph's Healthcare
ClinicalTrials.gov Identifier: NCT00186784     History of Changes
Other Study ID Numbers: TMS1871
First Submitted: September 13, 2005
First Posted: September 16, 2005
Last Update Posted: August 3, 2011
Last Verified: August 2011

Keywords provided by St. Joseph's Healthcare Hamilton:
Repetitive Transcranial Magnetic Stimulation
TMS

Additional relevant MeSH terms:
Depression
Depressive Disorder
Behavioral Symptoms
Mood Disorders
Mental Disorders