How Smoking Causes COPD: Examination of Immune System Changes
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|ClinicalTrials.gov Identifier: NCT00186719|
Recruitment Status : Unknown
Verified July 2011 by St. Joseph's Healthcare Hamilton.
Recruitment status was: Recruiting
First Posted : September 16, 2005
Last Update Posted : July 26, 2011
|Condition or disease|
|Chronic Obstructive Pulmonary Disease|
The mechanism by which smoking leads to damage to lung tissue in susceptible hosts, is uncertain. Recently there has been description of specific changes (that is reduction) in the number and activity of certain key immune cell types - dendritic cells- as a result of cigarette smoke exposure. This work was done in animal models and we would like to develop methods that will allow us to examine if similar changes occur in humans who smoke. Reduced number and activity of dendritic cells would be expected to lead to increased incidence of infection - a common problem in patients with COPD.
Since dendritic cells come to the lung from the bloodstream, and one can detect them in the circulation, we will look at the dendritic cells that are present in the peripheral blood.
|Study Type :||Observational|
|Estimated Enrollment :||100 participants|
|Official Title:||How Smoking Causes COPD: Examination of Immune System Changes|
|Study Start Date :||May 2005|
|Estimated Study Completion Date :||April 2012|
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00186719
|Contact: Susan E Carruthers, MLT||905-522-1155 ext firstname.lastname@example.org|
|Contact: Sarah E Goodwin, BA RRT CCRC||905-522-1155 ext email@example.com|
|St Joseph's Healthcare||Recruiting|
|Hamilton, Ontario, Canada, L8N 4A6|
|Contact: Gerard Cox, MB FRCPC FRCPI 905-522-1155 ext 5039 firstname.lastname@example.org|
|Contact: Martin Stampfli, PhD 905-525-9140 ext 22473 email@example.com|
|Principal Investigator: Gerard Cox, MB FRCPC FRCPI|
|Sub-Investigator: Martin Stampfli, PhD|
|Principal Investigator:||Gerard Cox, MB FRCPC FRCPI||McMaster University|