Non-Myeloablative Allogeneic Transplant for Myelodysplastic Syndromes and Myeloproliferative Disorders

This study has been completed.
National Institutes of Health (NIH)
Information provided by:
Stanford University Identifier:
First received: September 14, 2005
Last updated: October 13, 2010
Last verified: October 2010
To improve survival outcomes for patients with MDS and MPD with a nonmyeloablative allogeneic hematopoietic cell transplant.

Condition Intervention
Myelodysplastic Syndromes
Myeloproliferative Disorders
Blood and Marrow Transplant (BMT)
Myelodysplastic Syndromes (MDS)
Myeloproliferative Disorders (MPD)
Procedure: nonmyeloablative allogeneic hematopoietic cell transplant

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: Non-Myeloablative Allogeneic Hematopoietic Cell Transplantation for Treatment of Myelodysplastic Syndromes and Myeloproliferative Disorders (Except CML)

Resource links provided by NLM:

Further study details as provided by Stanford University:

Primary Outcome Measures:
  • Efficacy of transplant [ Time Frame: 1 year ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • safety profile of nonmyeloablative transplant, graft versus host disease, graft rejection, non-relapse mortality, use of donor lymphocyte infusion [ Time Frame: 1 year ] [ Designated as safety issue: Yes ]

Estimated Enrollment: 40
Study Start Date: December 2001
Study Completion Date: July 2010
Primary Completion Date: March 2004 (Final data collection date for primary outcome measure)
Detailed Description:
Non-Myeloablative Allogeneic Hematopoietic Cell Transplantation for Treatment of Myelodysplastic Syndromes and Myeloproliferative Disorders (Except CML)

Ages Eligible for Study:   18 Years to 75 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No

Inclusion Criteria:- Myelodysplastic Syndromes

  • Myeloproliferative Disorders
  • HLA matched donor available

Exclusion Criteria:- organ dysfunction

  • HIV positive
  Contacts and Locations
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Please refer to this study by its identifier: NCT00186576

United States, California
Stanford University School of Medicine
Stanford, California, United States, 94305
Sponsors and Collaborators
Stanford University
National Institutes of Health (NIH)
Principal Investigator: Ginna Laport Stanford University
  More Information

Responsible Party: Ginna Laport, Stanford University School of Medicine Identifier: NCT00186576     History of Changes
Obsolete Identifiers: NCT00052546
Other Study ID Numbers: BMT128, 75826, BMT128
Study First Received: September 14, 2005
Last Updated: October 13, 2010
Health Authority: United States: Institutional Review Board

Additional relevant MeSH terms:
Myelodysplastic Syndromes
Myeloproliferative Disorders
Bone Marrow Diseases
Hematologic Diseases
Pathologic Processes
Precancerous Conditions processed this record on November 27, 2015