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Transplantation for Patients With Chronic Lymphocytic Leukemia

This study has been completed.
Information provided by (Responsible Party):
Robert Negrin, Stanford University Identifier:
First received: September 13, 2005
Last updated: December 13, 2012
Last verified: December 2012
To evaluate the role of high dose therapy and autologous or allogeneic hematopoietic cell transplantation for the treatment of chronic lymphocytic leukemia.

Condition Intervention
Leukemia, Lymphocytic, Chronic Procedure: high dose chemotherapy then autologous hematopoietic cell transplant Procedure: ablative allogeneic hematopoietic cell transplant

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: Autologous and Allogeneic Peripheral Blood Progenitor (PBPC) Transplantation for Patients With Chronic Lymphocytic Leukemia

Resource links provided by NLM:

Further study details as provided by Robert Negrin, Stanford University:

Primary Outcome Measures:
  • Efficacy

Secondary Outcome Measures:
  • Feasibility
  • Toxicity
  • olymerase Chain Reaction (PCR) for minimal residual disease

Estimated Enrollment: 28
Study Start Date: November 1996
Study Completion Date: March 2010
Primary Completion Date: March 2010 (Final data collection date for primary outcome measure)
Detailed Description:
To determine effectiveness of allogeneic transplantation in eradicating chronic lymphocytic leukemia.

Ages Eligible for Study:   18 Years to 60 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:- adequate organ function - normal bone marrow cytogenetics

Exclusion Criteria:- active CNS disease

- For autologous patients more than 30% bone marrow involvement

  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00186303

United States, California
Stanford University School of Medicine
Stanford, California, United States, 94305
Sponsors and Collaborators
Stanford University
Principal Investigator: Robert S Negrin Stanford University
  More Information

Responsible Party: Robert Negrin, Professor, Stanford University Identifier: NCT00186303     History of Changes
Other Study ID Numbers: BMT88
Study First Received: September 13, 2005
Last Updated: December 13, 2012

Additional relevant MeSH terms:
Leukemia, Lymphoid
Leukemia, Lymphocytic, Chronic, B-Cell
Neoplasms by Histologic Type
Lymphoproliferative Disorders
Lymphatic Diseases
Immunoproliferative Disorders
Immune System Diseases
Leukemia, B-Cell processed this record on September 19, 2017