Try our beta test site
IMPORTANT: Listing of a study on this site does not reflect endorsement by the National Institutes of Health. Talk with a trusted healthcare professional before volunteering for a study. Read more...

Stem Cell Transplant From Matched Unrelated or Partially Matched Related Donors

This study has been completed.
Information provided by:
Stanford University Identifier:
First received: September 13, 2005
Last updated: July 23, 2010
Last verified: July 2010
To evaluate the use of unrelated donors for hematopoietic cell transplantation in the treatment of hematologic and lymphoid malignancies.

Condition Intervention
Blood Cancer
Blood and Marrow Transplant (BMT)
Procedure: ablative allogeneic hematopoietic cell transplantation

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: Stem Cell Transplantation From Matched Unrelated or Partially Matched Related Donors Using a Preparatory Regimen Consisting of Fractionated Total Body Irradiation (FTBI) and Cyclophosphamide (CY)

Further study details as provided by Stanford University:

Primary Outcome Measures:
  • oxicity and efficacy of TBI and cyclophosphamide as preparation for hematopoietic cell transplantation from partially matched and unrelated donors.

Secondary Outcome Measures:
  • Overall Survival
  • Event Free Survival

Estimated Enrollment: 250
Study Start Date: November 1989
Study Completion Date: May 2010
Primary Completion Date: June 2007 (Final data collection date for primary outcome measure)
Detailed Description:
Stem Cell Transplantation from Matched Unrelated or Partially Matched Related Donors Using a Preparatory Regimen Consisting of Fractionated Total Body Irradiation (FTBI) and Cyclophosphamide (CY). To administer high dose radio-chemotherapy followed by stem cell transplantation from a matched unrelated donor or a partially matched related donor.

Ages Eligible for Study:   up to 50 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:- acute leukemia

  • chronic leukemia
  • lymphoblastic lymphoma
  • MDS
  • MPS

Exclusion Criteria:- organ dysfunction

- HIV positive

  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00186225

United States, California
Stanford University School of Medicine
Stanford, California, United States, 94305
Sponsors and Collaborators
Stanford University
Principal Investigator: Laura Johnston Stanford University
  More Information

Responsible Party: Laura Johnston, Stanford University School of Medicine Identifier: NCT00186225     History of Changes
Other Study ID Numbers: BMT22
Study First Received: September 13, 2005
Last Updated: July 23, 2010

Additional relevant MeSH terms:
Hematologic Neoplasms
Neoplasms by Site
Hematologic Diseases processed this record on May 25, 2017