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Stem Cell Transplant From Matched Unrelated or Partially Matched Related Donors

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00186225
First Posted: September 16, 2005
Last Update Posted: July 27, 2010
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
Stanford University
  Purpose
To evaluate the use of unrelated donors for hematopoietic cell transplantation in the treatment of hematologic and lymphoid malignancies.

Condition Intervention
Blood Cancer Blood and Marrow Transplant (BMT) Procedure: ablative allogeneic hematopoietic cell transplantation

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: Stem Cell Transplantation From Matched Unrelated or Partially Matched Related Donors Using a Preparatory Regimen Consisting of Fractionated Total Body Irradiation (FTBI) and Cyclophosphamide (CY)

Further study details as provided by Stanford University:

Primary Outcome Measures:
  • oxicity and efficacy of TBI and cyclophosphamide as preparation for hematopoietic cell transplantation from partially matched and unrelated donors.

Secondary Outcome Measures:
  • Overall Survival
  • Event Free Survival

Estimated Enrollment: 250
Study Start Date: November 1989
Study Completion Date: May 2010
Primary Completion Date: June 2007 (Final data collection date for primary outcome measure)
Detailed Description:
Stem Cell Transplantation from Matched Unrelated or Partially Matched Related Donors Using a Preparatory Regimen Consisting of Fractionated Total Body Irradiation (FTBI) and Cyclophosphamide (CY). To administer high dose radio-chemotherapy followed by stem cell transplantation from a matched unrelated donor or a partially matched related donor.
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   up to 50 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:- acute leukemia

  • chronic leukemia
  • lymphoblastic lymphoma
  • MDS
  • MPS

Exclusion Criteria:- organ dysfunction

- HIV positive

  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00186225


Locations
United States, California
Stanford University School of Medicine
Stanford, California, United States, 94305
Sponsors and Collaborators
Stanford University
Investigators
Principal Investigator: Laura Johnston Stanford University
  More Information

Responsible Party: Laura Johnston, Stanford University School of Medicine
ClinicalTrials.gov Identifier: NCT00186225     History of Changes
Other Study ID Numbers: BMT22
75268
First Submitted: September 13, 2005
First Posted: September 16, 2005
Last Update Posted: July 27, 2010
Last Verified: July 2010

Additional relevant MeSH terms:
Hematologic Neoplasms
Neoplasms by Site
Neoplasms
Hematologic Diseases