Magnesium Sulfate Versus Nifedipine for the Acute Tocolysis of Preterm Labor: A Prospective, Randomized Trial
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|ClinicalTrials.gov Identifier: NCT00185900|
Recruitment Status : Completed
First Posted : September 16, 2005
Last Update Posted : May 27, 2016
|Condition or disease||Intervention/treatment||Phase|
|Obstetric Labor, Premature||Drug: Magnesium Sulfate Drug: Nifedipine||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||192 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Official Title:||Magnesium Sulfate Versus Nifedipine for the Acute Tocolysis of Preterm Labor: A Prospective, Randomized Trial|
|Study Start Date :||April 1999|
|Actual Primary Completion Date :||July 2005|
|Actual Study Completion Date :||July 2007|
Active Comparator: Magnesium Sulfate
Preterm labor treatment with Magnesium Sulfate.
Drug: Magnesium Sulfate
Preterm labor treatment with Magnesium Sulfate 4 gram bolus followed by 2 gm per hour infusion. 2 Gm bolus as needed and/or rate increase up to 4gm per hour were allowed at the discretion of the treating physician.
Active Comparator: Nifedipine
Preterm labor treatment with Nifedipine.
Preterm labor treatment with Nifedipine 10 mg. sublingually every 20 minutes for three doses, followed by 20 mg. orally every 4 or 6 hours.
- No delivery in 48 hours and uterine quiescence [ Time Frame: 48 hours after administration of study medication. ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00185900
|United States, California|
|Stanford University School of Medicine|
|Stanford, California, United States, 94305|
|Principal Investigator:||Yasser Yehia El-Sayed||Stanford University|