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Evaluation of Metabolic Activity of Liver Metastases by FDG-PET Scanning

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ClinicalTrials.gov Identifier: NCT00184782
Recruitment Status : Unknown
Verified September 2005 by Radboud University.
Recruitment status was:  Recruiting
First Posted : September 16, 2005
Last Update Posted : September 21, 2007
Sponsor:
Information provided by:
Radboud University

Brief Summary:
The purpose of this study is to evaluate the effect of primary tumor resection on the metabolic activity of metastases in patients with a colorectal primary tumor and synchronous liver metastases by positron emission tomography (PET) with 2-deoxy-2-fluoro[18F]-D-glucose (FDG-PET) scanning.

Condition or disease Intervention/treatment Phase
Colorectal Neoplasms Procedure: FDG-PET Not Applicable

Detailed Description:
The goal of this study is to evaluate the activity of liver metastases before and after resection of the primary tumor. Non-invasive assessment of tumor metabolism is possible in vivo by means of positron emission tomography (PET)-scanning. Therefore, FDG-PET scan offers a suitable approach to determine the influence of removal of a primary colorectal tumor on metabolic activity of the liver metastases. The FDG uptake in the liver metastases is quantified by calculating standardised uptake values (SUVs).

Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 30 participants
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Diagnostic
Official Title: Exploratory Study on FDG-PET Scanning in Evaluating the Metabolic Activity of Liver Metastases Before and After Resection of the Primary Tumor in Patients With a Colorectal Malignancy
Study Start Date : September 2003
Estimated Study Completion Date : December 2008

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Nuclear Scans
U.S. FDA Resources




Primary Outcome Measures :
  1. Increase in metabolic activity of liver metastases after resection of the primary tumor compared to the activity of metastases in patients without primary tumor resection


Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Colorectal cancer and synchronous liver metastases

Exclusion Criteria:

  • Pregnancy

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00184782


Contacts
Contact: Charlotte Peeters, MD +31-24-3611111 ext 17365 C.Peeters@chir.umcn.nl
Contact: Theo Ruers, PhD +31-24-3611111 ext 17365 T.Ruers@chir.umcn.nl

Locations
Netherlands
Radboud University Nijmegen Medical Centre Recruiting
Nijmegen, Gelderland, Netherlands, 6500 HB
Contact: Charlotte Peeters, MD    +31-24-3611111 ext 17365    C.Peeters@chir.umcn.nl   
Contact: Theo Ruers, PhD    +31-24-3611111 ext 17365    T.Ruers@chir.umcn.nl   
Sponsors and Collaborators
Radboud University
Investigators
Principal Investigator: Theo Ruers, PhD Radboud University

ClinicalTrials.gov Identifier: NCT00184782     History of Changes
Other Study ID Numbers: CP 2005
First Posted: September 16, 2005    Key Record Dates
Last Update Posted: September 21, 2007
Last Verified: September 2005

Keywords provided by Radboud University:
colorectal cancer
liver metastases
metabolic activity

Additional relevant MeSH terms:
Neoplasm Metastasis
Colorectal Neoplasms
Neoplastic Processes
Neoplasms
Pathologic Processes
Intestinal Neoplasms
Gastrointestinal Neoplasms
Digestive System Neoplasms
Neoplasms by Site
Digestive System Diseases
Gastrointestinal Diseases
Colonic Diseases
Intestinal Diseases
Rectal Diseases