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Evaluation of Metabolic Activity of Liver Metastases by FDG-PET Scanning

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified September 2005 by Radboud University.
Recruitment status was:  Recruiting
Sponsor:
ClinicalTrials.gov Identifier:
NCT00184782
First Posted: September 16, 2005
Last Update Posted: September 21, 2007
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
Radboud University
  Purpose
The purpose of this study is to evaluate the effect of primary tumor resection on the metabolic activity of metastases in patients with a colorectal primary tumor and synchronous liver metastases by positron emission tomography (PET) with 2-deoxy-2-fluoro[18F]-D-glucose (FDG-PET) scanning.

Condition Intervention
Colorectal Neoplasms Procedure: FDG-PET

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Diagnostic
Official Title: Exploratory Study on FDG-PET Scanning in Evaluating the Metabolic Activity of Liver Metastases Before and After Resection of the Primary Tumor in Patients With a Colorectal Malignancy

Resource links provided by NLM:


Further study details as provided by Radboud University:

Primary Outcome Measures:
  • Increase in metabolic activity of liver metastases after resection of the primary tumor compared to the activity of metastases in patients without primary tumor resection

Estimated Enrollment: 30
Study Start Date: September 2003
Estimated Study Completion Date: December 2008
Detailed Description:
The goal of this study is to evaluate the activity of liver metastases before and after resection of the primary tumor. Non-invasive assessment of tumor metabolism is possible in vivo by means of positron emission tomography (PET)-scanning. Therefore, FDG-PET scan offers a suitable approach to determine the influence of removal of a primary colorectal tumor on metabolic activity of the liver metastases. The FDG uptake in the liver metastases is quantified by calculating standardised uptake values (SUVs).
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Colorectal cancer and synchronous liver metastases

Exclusion Criteria:

  • Pregnancy
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00184782


Contacts
Contact: Charlotte Peeters, MD +31-24-3611111 ext 17365 C.Peeters@chir.umcn.nl
Contact: Theo Ruers, PhD +31-24-3611111 ext 17365 T.Ruers@chir.umcn.nl

Locations
Netherlands
Radboud University Nijmegen Medical Centre Recruiting
Nijmegen, Gelderland, Netherlands, 6500 HB
Contact: Charlotte Peeters, MD    +31-24-3611111 ext 17365    C.Peeters@chir.umcn.nl   
Contact: Theo Ruers, PhD    +31-24-3611111 ext 17365    T.Ruers@chir.umcn.nl   
Sponsors and Collaborators
Radboud University
Investigators
Principal Investigator: Theo Ruers, PhD Radboud University
  More Information

ClinicalTrials.gov Identifier: NCT00184782     History of Changes
Other Study ID Numbers: CP 2005
First Submitted: September 12, 2005
First Posted: September 16, 2005
Last Update Posted: September 21, 2007
Last Verified: September 2005

Keywords provided by Radboud University:
colorectal cancer
liver metastases
metabolic activity

Additional relevant MeSH terms:
Neoplasm Metastasis
Colorectal Neoplasms
Neoplastic Processes
Neoplasms
Pathologic Processes
Intestinal Neoplasms
Gastrointestinal Neoplasms
Digestive System Neoplasms
Neoplasms by Site
Digestive System Diseases
Gastrointestinal Diseases
Colonic Diseases
Intestinal Diseases
Rectal Diseases