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Effect of Increased Oxygenation in the Air During Endurance Training in Stable Angina Pectoris Patients

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
 
ClinicalTrials.gov Identifier: NCT00184444
Recruitment Status : Completed
First Posted : September 16, 2005
Last Update Posted : July 20, 2016
Sponsor:
Collaborator:
Aarhus University Hospital
Information provided by (Responsible Party):
Norwegian University of Science and Technology

Study Description
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Brief Summary:

The study investigates whether endurance training breathing 100% oxygen gives a additional improvement of maximal oxygen uptake in stable Angina Pectoris patients, compared to training without extra oxygen supplementation. In addition work economy, stroke volume and cardiac perfusion is measured.

The hypothesis of the study is that increased oxygenation of the air increases performance, stroke volume, work economy and cardiac perfusion.


Condition or disease Intervention/treatment Phase
Angina Pectoris Behavioral: Hypoxic interval training Behavioral: Normoxic interval training Not Applicable

Study Design
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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 25 participants
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: Effect of Increased Oxygenation in the Air During Endurance Training in Stable Angina Pectoris Patients
Study Start Date : September 2004
Actual Primary Completion Date : July 2007
Actual Study Completion Date : July 2007

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Angina

Arms and Interventions
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Arm Intervention/treatment
Experimental: Hypoxic Interval training
4 x 4 minutes interval training with 100% oxygenated air
 Behavioral: Hypoxic interval training
4 x 4 minutes interval training in hypoxic air, 3 times per week at 90-95% HR max
Experimental: Normoxic interval training
4 x 4 minutes interval training in normoxic air
 Behavioral: Normoxic interval training
4 x 4 minutes normoxic interval training, 3 times per week at 90-95% HR max


Outcome Measures
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Primary Outcome Measures :
  1. maximal oxygen uptake [ Time Frame: Baseline and post training ]

Secondary Outcome Measures :
  1. Cardiac perfusion [ Time Frame: Baseline and post training ]
  2. work economy [ Time Frame: Baseline and post training ]
  3. cardiac output [ Time Frame: baseline and post training ]

Eligibility Criteria
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Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 75 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • stable angina pectoris age 18-75

Exclusion Criteria:

  • unstable angina pectoris
  • Limitations to exercise other than coronary artery disease
  • Participants in other study interventions
Contacts and Locations
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Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00184444


Locations
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Norway
Norwegian University of Science and Technology
Trondheim, Norway, 7489
Sponsors and Collaborators
Norwegian University of Science and Technology
Aarhus University Hospital
Investigators
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Study Director: Asbjørn Støylen, MD Norwegian university of sience and technology
More Information
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Publications of Results:

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Responsible Party: Norwegian University of Science and Technology
ClinicalTrials.gov Identifier: NCT00184444    
Other Study ID Numbers: 094-2004
First Posted: September 16, 2005    Key Record Dates
Last Update Posted: July 20, 2016
Last Verified: July 2016
Keywords provided by Norwegian University of Science and Technology:
angina pectoris
hyperoxia
endurance training
stroke volume
cardiac perfusion
Additional relevant MeSH terms:
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Angina Pectoris
Angina, Stable
Myocardial Ischemia
Heart Diseases
Cardiovascular Diseases
 Vascular Diseases
Chest Pain
Pain
Neurologic Manifestations