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Effect of Increased Oxygenation in the Air During Endurance Training in Stable Angina Pectoris Patients

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
ClinicalTrials.gov Identifier: NCT00184444
Recruitment Status : Completed
First Posted : September 16, 2005
Last Update Posted : July 20, 2016
Sponsor:
Collaborator:
Aarhus University Hospital
Information provided by (Responsible Party):
Norwegian University of Science and Technology

Brief Summary:

The study investigates whether endurance training breathing 100% oxygen gives a additional improvement of maximal oxygen uptake in stable Angina Pectoris patients, compared to training without extra oxygen supplementation. In addition work economy, stroke volume and cardiac perfusion is measured.

The hypothesis of the study is that increased oxygenation of the air increases performance, stroke volume, work economy and cardiac perfusion.


Condition or disease Intervention/treatment
Angina Pectoris Behavioral: Hypoxic interval training Behavioral: Normoxic interval training

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 25 participants
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: Effect of Increased Oxygenation in the Air During Endurance Training in Stable Angina Pectoris Patients
Study Start Date : September 2004
Primary Completion Date : July 2007
Study Completion Date : July 2007

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Angina
U.S. FDA Resources

Arm Intervention/treatment
Experimental: Hypoxic Interval training
4 x 4 minutes interval training with 100% oxygenated air
Behavioral: Hypoxic interval training
4 x 4 minutes interval training in hypoxic air, 3 times per week at 90-95% HR max
Experimental: Normoxic interval training
4 x 4 minutes interval training in normoxic air
Behavioral: Normoxic interval training
4 x 4 minutes normoxic interval training, 3 times per week at 90-95% HR max



Primary Outcome Measures :
  1. maximal oxygen uptake [ Time Frame: Baseline and post training ]

Secondary Outcome Measures :
  1. Cardiac perfusion [ Time Frame: Baseline and post training ]
  2. work economy [ Time Frame: Baseline and post training ]
  3. cardiac output [ Time Frame: baseline and post training ]


Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 75 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • stable angina pectoris age 18-75

Exclusion Criteria:

  • unstable angina pectoris
  • Limitations to exercise other than coronary artery disease
  • Participants in other study interventions

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00184444


Locations
Norway
Norwegian University of Science and Technology
Trondheim, Norway, 7489
Sponsors and Collaborators
Norwegian University of Science and Technology
Aarhus University Hospital
Investigators
Study Director: Asbjørn Støylen, MD Norwegian university of sience and technology

Publications:
Responsible Party: Norwegian University of Science and Technology
ClinicalTrials.gov Identifier: NCT00184444     History of Changes
Other Study ID Numbers: 094-2004
First Posted: September 16, 2005    Key Record Dates
Last Update Posted: July 20, 2016
Last Verified: July 2016

Keywords provided by Norwegian University of Science and Technology:
angina pectoris
hyperoxia
endurance training
stroke volume
cardiac perfusion

Additional relevant MeSH terms:
Angina Pectoris
Angina, Stable
Chest Pain
Pain
Neurologic Manifestations
Nervous System Diseases
Myocardial Ischemia
Heart Diseases
Cardiovascular Diseases
Vascular Diseases
Signs and Symptoms