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The Immune System and Psychiatric Disorders

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ClinicalTrials.gov Identifier: NCT00184418
Recruitment Status : Completed
First Posted : September 16, 2005
Last Update Posted : March 13, 2017
Sponsor:
Collaborator:
Information provided by (Responsible Party):

Study Description
Brief Summary:
The study is based on a hypothesis that there is interaction between the activity in the immune system and in the mind. To study this, the investigators register different measures for activity in the immune system on patients unselectedly admitted to an acute psychiatric ward. The psychiatric statuses and diagnoses of these patients are carefully defined as well.

Condition or disease
Stress Disorders, Traumatic Depressive Disorder Bipolar Disorder Personality Disorders Schizophrenia Psychotic Disorders

Detailed Description:

Our hypotheses are first that activity in the immune system influences the psychiatric status in general, second that changes in activity in psychiatric status affect activity in the immune system and third that there are connections between certain psychiatric conditions/disorders and certain features of the immune system.

All patients admitted to a psychiatric acute ward covering an area with a population of 130.000 and with around 1000 admittances to an acute psychiatric ward a year (some readmittances) are asked to participate in the study. Patients fill in a question form regarding psychiatric as well as somatic health with emphasis on diseases involving immune activity. When possible also slight information on the family is registered. Both at the time of admittance and after recovery clinical laboratory tests on somatic status are registered. In addition the level of different cytokines is measured. The psychiatric state and precise diagnoses are registered during the stay. The data will be analysed to uncover connections between psychiatric stress in general as well as specific psychiatric diagnoses and activity in the immune system.


Study Design

Study Type : Observational
Actual Enrollment : 1400 participants
Observational Model: Cohort
Time Perspective: Cross-Sectional
Official Title: The Immune System and Psychiatric Disorders
Actual Study Start Date : January 2005
Primary Completion Date : January 2008
Study Completion Date : January 2008

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Mental Disorders
U.S. FDA Resources

Groups and Cohorts

Group/Cohort
All patients admitted to a psychiatric acute ward


Outcome Measures

Primary Outcome Measures :
  1. cytokines [ Time Frame: 1 year ]

Biospecimen Retention:   Samples Without DNA
Serum, frozen

Eligibility Criteria

Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
Adults aged 18 years and above. Amitted to psychiatric acute ward of St Olavs Hospital, Trondheim, Norway.
Criteria

Inclusion Criteria:

  • Admission to the adult acute psychiatric ward of a certain geographical area during the study period

Exclusion Criteria:

  • Patients that do not agree to participate in the study
Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00184418


Locations
Norway
St Olavs Hospital, Department of Psychiatry, Østmarka Hospital
Trondheim, Middle Norway, Norway, N-7040
Sponsors and Collaborators
Norwegian University of Science and Technology
St. Olavs Hospital
Investigators
Study Chair: Solveig K Reitan, MD, PhD St Olavs Hospital/NTNU
More Information

Publications:
Responsible Party: Norwegian University of Science and Technology
ClinicalTrials.gov Identifier: NCT00184418     History of Changes
Other Study ID Numbers: 94463
First Posted: September 16, 2005    Key Record Dates
Last Update Posted: March 13, 2017
Last Verified: March 2017
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No

Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No

Keywords provided by Norwegian University of Science and Technology:
Immunity
Immune System
Cytokines
Psychophysiology
Psychoneuroimmunology

Additional relevant MeSH terms:
Disease
Schizophrenia
Depressive Disorder
Depression
Bipolar Disorder
Personality Disorders
Psychotic Disorders
Mental Disorders
Problem Behavior
Stress Disorders, Traumatic
Pathologic Processes
Schizophrenia Spectrum and Other Psychotic Disorders
Mood Disorders
Behavioral Symptoms
Bipolar and Related Disorders
Trauma and Stressor Related Disorders