The Immune System and Psychiatric Disorders

This study has been completed.
St. Olavs Hospital
Information provided by (Responsible Party):
Norwegian University of Science and Technology Identifier:
First received: September 15, 2005
Last updated: April 7, 2015
Last verified: April 2015
The study is based on a hypothesis that there is interaction between the activity in the immune system and in the mind. To study this, the investigators register different measures for activity in the immune system on patients unselectedly admitted to an acute psychiatric ward. The psychiatric statuses and diagnoses of these patients are carefully defined as well.

Personality Disorders

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Cross-Sectional
Official Title: The Immune System and Psychiatric Disorders

Resource links provided by NLM:

Further study details as provided by Norwegian University of Science and Technology:

Primary Outcome Measures:
  • cytokines [ Time Frame: 1 year ] [ Designated as safety issue: No ]

Biospecimen Retention:   Samples Without DNA
Serum, frozen

Enrollment: 1400
Study Start Date: January 2005
Study Completion Date: January 2008
Primary Completion Date: January 2008 (Final data collection date for primary outcome measure)
All patients admitted to a psychiatric acute ward

Detailed Description:

Our hypotheses are first that activity in the immune system influences the psychiatric status in general, second that changes in activity in psychiatric status affect activity in the immune system and third that there are connections between certain psychiatric conditions/disorders and certain features of the immune system.

All patients admitted to a psychiatric acute ward covering an area with a population of 130.000 and with around 1000 admittances to an acute psychiatric ward a year (some readmittances) are asked to participate in the study. Patients fill in a question form regarding psychiatric as well as somatic health with emphasis on diseases involving immune activity. When possible also slight information on the family is registered. Both at the time of admittance and after recovery clinical laboratory tests on somatic status are registered. In addition the level of different cytokines is measured. The psychiatric state and precise diagnoses are registered during the stay. The data will be analysed to uncover connections between psychiatric stress in general as well as specific psychiatric diagnoses and activity in the immune system.


Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
Adults aged 18 years and above. ADmitted to psychiatric acute ward.

Inclusion Criteria:

  • Admission to the adult acute psychiatric ward of a certain geographical area during the study period

Exclusion Criteria:

  • Patients that do not agree to participate in the study
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00184418

St Olavs Hospital, Department of Psychiatry, Østmarka Hospital
Trondheim, Middle Norway, Norway, N-7040
Sponsors and Collaborators
Norwegian University of Science and Technology
St. Olavs Hospital
Study Chair: Solveig K Reitan, MD, PhD St Olavs Hospital/NTNU
  More Information

No publications provided

Responsible Party: Norwegian University of Science and Technology Identifier: NCT00184418     History of Changes
Other Study ID Numbers: 94463, 11771
Study First Received: September 15, 2005
Last Updated: April 7, 2015
Health Authority: Norway: Norwegian Social Science Data Services

Keywords provided by Norwegian University of Science and Technology:
Immune system
Psychic trauma
Personality disorder
Bipolar disorder

Additional relevant MeSH terms:
Mental Disorders
Personality Disorders
Pathologic Processes
Schizophrenia and Disorders with Psychotic Features processed this record on November 27, 2015