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Cardiovascular Risk Factors in Overweight Adolescents

This study has been completed.
St. Olavs Hospital
Information provided by (Responsible Party):
Norwegian University of Science and Technology Identifier:
First received: September 13, 2005
Last updated: March 29, 2017
Last verified: March 2017
The aim of the present study was to determine the effects of either a multidisciplinary approach or intensity-controlled interval training on cardiovascular risk factors in overweight adolescents.

Condition Intervention
Overweight Obesity Behavioral: Multitreatment approach Behavioral: Aerobic interval training

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Outcomes Assessor
Primary Purpose: Treatment
Official Title: Aerobic Interval Training Reduces Cardiovascular Risk Factors More Than a Multitreatment Approach in Overweight Adolescents

Further study details as provided by Norwegian University of Science and Technology:

Primary Outcome Measures:
  • VO2max change [ Time Frame: 3 months and 12 months ]
    maximal oxygen uptake change

Secondary Outcome Measures:
  • Cardiovascular risk factors [ Time Frame: 2 years ]
  • endothelial function change [ Time Frame: 3 months and 12 months ]
    measured as FMD (flow-mediated dilution) using high-resolution vascular ultrasound

Enrollment: 54
Actual Study Start Date: February 2005
Study Completion Date: May 2008
Primary Completion Date: February 2008 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: Aerobic interval training
Aerobic interval training (AIT)
Behavioral: Aerobic interval training
Walking/running 'uphill' on a treadmill twice a week for 3 months. 10 min warming-up at 70% of Hfmax before performing 4x4 intervals at 90-95% of Hfmax. 3 min active recovery at 70% of Hfmax between each interval. 5 min cool-down period, giving a total of 40 min.
Active Comparator: Multitreatment approach
multitreatment approach (MTG)
Behavioral: Multitreatment approach
12 months regimen consisting of group meetings every 2 weeks involving a physician, psychologist, physiotherapist and clinical nutritional physiologist. 21 h treatment during the first 3 months: 3 activity sessions (3 h) and 3 group conversations (4 h). Attendance inclusion criterium was set to minimum of 80%
Other Name: multidisciplinary approach

Detailed Description:
Several approaches have been used to improve cardiovascular health status and quality of life in obese children and adolescents, without coming to a consensus decision. Recently, a few studies have determined the effects of exercise training and diet on endothelial function in overweight and obese children and adolescents. The main findings are that only a moderate amount of exercise training and diet changes improves or restores endothelial function. It is difficult, however, to asses the separate effects of the training and diet, particularly because none of the studies have used a homogenous exercise training regimen. Unanimously, better, but affordable prevention and treatment strategies to improve wide-scale health outcome are called upon to slow down the current epidemic of overweight. It is now well established that physical activity reduces, but does not currently prevent the epidemic of obesity from either reaching global proportions or taxing public health and economy. Despite the recent advances in understanding the responsible biology of improved cardiovascular health with exercise training, several lines of research questions are still unresolved. For instance, the optimal program, e.g. when to initiate, whom to prescribe exercise to, which exercise-intensity is required, and the actual design of the treatment program, remain by far yet to determine.

Ages Eligible for Study:   13 Years to 16 Years   (Child)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Overweight and obese adolescents in the Trondheim area, referred to medical treatment at St. Olav's Hospital

Exclusion Criteria:

  • Any coexisting medical illnesses
  Contacts and Locations
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Please refer to this study by its identifier: NCT00184236

The Norwegian University of Science and Technology
Trondheim, Sør-Trøndelag, Norway, 7030
Sponsors and Collaborators
Norwegian University of Science and Technology
St. Olavs Hospital
Study Chair: Ulrik Wisløff, PhD prof Norwegian University of Science and Technology
  More Information

Responsible Party: Norwegian University of Science and Technology Identifier: NCT00184236     History of Changes
Other Study ID Numbers: ts-aet01
Study First Received: September 13, 2005
Last Updated: March 29, 2017
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No

Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No

Keywords provided by Norwegian University of Science and Technology:
Exercise Training
Cardiovascular diseases
Risk factors

Additional relevant MeSH terms:
Body Weight
Signs and Symptoms processed this record on August 16, 2017